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Pathway Description
Betazole Action Pathway
Homo sapiens
Drug Action Pathway
Betazole, also known as ametazole and Histalog, is a histamine H2 agonist that causes an increase in gastric acid secretion. Betazole is commonly used to evaluate acid production. Betazole binds to the H2 receptor to enhance the G protein signaling cascade to increase gastric secretion into the lumen. Gastric acid digests protein and absorbs calcium, iron and vitamin B12. Gastric acidity may also interfere with medication bioavailability. Measuring gastric acid secretion is useful to manage diseases involving acid production such as gastroesophageal reflux disease.
References
Betazole Pathway References
SCOBIE BA: HISTALOG (AMETAZOLE HYDROCHLORIDE) AS A SUBSTITUTE FOR HISTAMINE IN DETERMINATION OF MAXIMAL ACID OUTPUT. Br Med J. 1965 May 15;1(5445):1287-8.
Pubmed: 14278820
Wruble LD, Cummins AJ, Goldenberg J, Schapiro H: The effect of intravenous histalog on gastric secretion in man. Am J Dig Dis. 1967 Nov;12(11):1087-9.
Pubmed: 6057052
Schubert ML: Gastric secretion. Curr Opin Gastroenterol. 2014 Nov;30(6):578-82. doi: 10.1097/MOG.0000000000000125.
Pubmed: 25211241
Gastric Acid Production References
Wolfe MM, Soll AH: The physiology of gastric acid secretion. N Engl J Med. 1988 Dec 29;319(26):1707-15. doi: 10.1056/NEJM198812293192605.
Pubmed: 3060722
Schubert ML: Gastric acid secretion. Curr Opin Gastroenterol. 2016 Nov;32(6):452-460. doi: 10.1097/MOG.0000000000000308.
Pubmed: 27607343
Schubert ML: Functional anatomy and physiology of gastric secretion. Curr Opin Gastroenterol. 2015 Nov;31(6):479-85. doi: 10.1097/MOG.0000000000000213.
Pubmed: 26376477
Heitzmann D, Warth R: No potassium, no acid: K+ channels and gastric acid secretion. Physiology (Bethesda). 2007 Oct;22:335-41. doi: 10.1152/physiol.00016.2007.
Pubmed: 17928547
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