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Uncharacterized
protein YbjE
2-
isopropylmalate
synthase
3-
isopropylmalate
dehydratase
large subunit
3-
isopropylmalate
dehydratase
small subunit
3-
isopropylmalate
dehydratase
large subunit
3-
isopropylmalate
dehydratase
small subunit
D-malate
dehydrogenase
[decarboxylating]
Aromatic-
amino-acid
aminotransferase
3-Methyl-2-
oxovaleric acid
L-Leucine
L-Leucine
H
2
O
Acetyl-CoA
CoA
H
+
2-
Isopropylmalic
acid
H
2
O
Isopropylmaleate
H
2
O
3-
Isopropylmalate
NAD
NADH
H
+
2-Isopropyl- 3-
oxosuccinate
H
+
CO
2
Ketoleucine
L-Glutamic acid
Oxoglutaric
acid
Isoleucine
Biosynthesis
3-
isopropylmalate
dehydrogenase
Branched-
chain-amino-
acid
aminotransferase
ybjE
leuA
leuC
leuD
leuC
leuD
dmlA
tyrB
3-Methyl-2-
oxovaleric acid
L-Leucine
L-Leucine
Water
Acetyl-CoA
Coenzyme A
Hydrogen Ion
2-
Isopropylmalic
acid
Water
Isopropylmaleate
Water
3-
Isopropylmalate
NAD
NADH
Hydrogen Ion
2-Isopropyl- 3-
oxosuccinate
Hydrogen Ion
Carbon dioxide
Ketoleucine
L-Glutamic acid
Oxoglutaric
acid
Isoleucine
Biosynthesis
leuB
ilvE
ybjE
leuA
leuC
leuD
leuC
leuD
dmlA
tyrB
3M2Oxva
Leu
Leu
H
2
O
Ac-CoA
CoA
H
+
2-Isopa
H
2
O
Isoprop
H
2
O
3Isopr
NAD
NADH
H
+
2ip3o
H
+
CO
2
Ketoleu
Glu
AKG
PW000818
leuB
ilvE