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Pyrazinamidase/nicotinamidase
NMN
amidohydrolase
Nicotinate-
nucleotide
adenylyltransferase
Transcriptional
regulator nadR
Transcriptional
regulator nadR
Nicotinate
phosphoribosyltransferase
NH(3)-dependent
NAD(+)
synthetase
NAD
NAD
H
2
O
H
+
AMP
β-nicotinamide
D-
ribonucleotide
H
2
O
H
+
D-ribofuranose
5-phosphate
Niacinamide
H
2
O
Ammonium
Nicotinic acid
H
2
O
Ammonium
nicotinate β-D-
ribonucleotide
ATP
H
+
PP
i
Nicotinic acid
adenine
dinucleotide
Nicotinamide
riboside
ATP
ADP
H
+
β-nicotinamide
D-
ribonucleotide
ATP
H
+
PP
i
H
2
O
P
i
NADP
H
2
O
P
i
H
2
O
ATP
Phosphoribosyl
pyrophosphate
P
i
ADP
PP
i
H
2
O
L-Glutamine
ATP
H
+
AMP
PP
i
L-Glutamic acid
NAD
Biosynthesis
pncA
pncC
nadD
nadR
nadR
pncB
nadE
NAD
NAD
Water
Hydrogen Ion
Adenosine
monophosphate
β-nicotinamide
D-
ribonucleotide
Water
Hydrogen Ion
D-ribofuranose
5-phosphate
Niacinamide
Water
Ammonium
Nicotinic acid
Water
Ammonium
nicotinate β-D-
ribonucleotide
Adenosine
triphosphate
Hydrogen Ion
Pyrophosphate
Nicotinic acid
adenine
dinucleotide
Nicotinamide
riboside
Adenosine
triphosphate
Adenosine
diphosphate
Hydrogen Ion
β-nicotinamide
D-
ribonucleotide
Adenosine
triphosphate
Hydrogen Ion
Pyrophosphate
Water
Phosphate
NADP
Water
Phosphate
Water
Adenosine
triphosphate
Phosphoribosyl
pyrophosphate
Phosphate
Adenosine
diphosphate
Pyrophosphate
Water
L-Glutamine
Adenosine
triphosphate
Hydrogen Ion
Adenosine
monophosphate
Pyrophosphate
L-Glutamic acid
NAD
Biosynthesis