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D-3-
phosphoglycerate
dehydrogenase
Phosphoserine
aminotransferase
Phosphoserine
phosphatase
Serine
acetyltransferase
NADP-dependent
L-serine/L-
allo-threonine
dehydrogenase
ydfG
3-Phosphoglyceric
acid
NAD
NADH
H
+
Phosphohydroxypyruvic
acid
L-Glutamic acid
Oxoglutaric acid
DL-O-
Phosphoserine
H
2
O
P
i
L-Serine
Acetyl-CoA
CoA
O-Acetylserine
Hydrogen sulfide
H
+
Acetic acid
L-Cysteine
2-Aminomalonate
semialdehyde
NADPH
H
+
NADP
Glycolate and
Glyoxylate
Degradation
Cysteine synthase
B
Cysteine synthase
A
Cytoplasm
Inner Membrane
Periplasmic Space
Gram-Negative Bacteria
Outer Membrane
serA
serC
serB
cysE
ydfG
3-Phosphoglyceric
acid
NAD
NADH
Hydrogen Ion
Phosphohydroxypyruvic
acid
L-Glutamic acid
Oxoglutaric acid
DL-O-
Phosphoserine
Water
Phosphate
L-Serine
Acetyl-CoA
Coenzyme A
O-Acetylserine
Hydrogen sulfide
Hydrogen Ion
Acetic acid
L-Cysteine
2-Aminomalonate
semialdehyde
NADPH
Hydrogen Ion
NADP
Glycolate and
Glyoxylate
Degradation
cysM
cysK
serA
serC
serB
cysE
ydfG
G3P
NAD
NADH
H
+
3POHPyr
Glu
AKG
DL-OPPr
H
2
O