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Amidophosphoribosyltransferase
Phosphoribosylamine-
-glycine ligase
Phosphoribosylglycinamide
formyltransferase
Phosphoribosylformylglycinamidine
synthase
Phosphoribosylformylglycinamidine
cyclo-ligase
Phosphomethylpyrimidine
synthase
Thiamine-
phosphate
pyrophosphorylase
Thiamine-
monophosphate
kinase
Phosphoribosylglycinamide
formyltransferase
2
Phosphoribosyl
pyrophosphate
H
2
O
L-Glutamine
5-
Phosphoribosylamine
L-Glutamic acid
PP
i
Glycine
ATP
N1-(5-
phospho-β-D-
ribosyl)glycinamide
P
i
ADP
H
+
10-formyl-
tetrahydrofolate
mono-L-
glutamate
H
+
tetrahydropteroyl
mono-L-
glutamate
5'-
Phosphoribosyl-
N-
formylglycinamide
H
2
O
L-Glutamine
ATP
2- (Formamido)-
N1-(5-
phospho-D-
ribosyl)acetamidine
L-Glutamic acid
P
i
ADP
H
+
ATP
5-
Aminoimidazole
ribonucleotide
P
i
ADP
H
+
S-
Adenosylmethionine
H
+
Carbon monoxide
Formic acid
L-Methionine
5'-
Deoxyadenosine
4-amino-2-
methyl-5-
phosphomethylpyrimidine
ATP
ADP
4-amino-2-
methyl-5-
diphosphomethylpyrimidine
2-((2R,5Z)-2-
Carboxy-4-
methylthiazol-
5(2H)-
ylidene)ethyl
phosphate
H
+
CO
2
PP
i
Thiamine
monophosphate
ATP
ADP
Thiamine
pyrophosphate
ATP
Formic acid
ADP
P
i
H
+
Magnesium
Magnesium
Potassium
Magnesium
NADPH
NADH
NADPH
S-
Adenosylmethionine
Magnesium
Magnesium
Hydroxymethylpyrimidine/phosphomethylpyrimidine
kinase
purF
purD
purN
purL
purM
thiC
thiE
thiL
purT
Phosphoribosyl
pyrophosphate
Water
L-Glutamine
5-
Phosphoribosylamine
L-Glutamic acid
Pyrophosphate
Glycine
Adenosine
triphosphate
N1-(5-
phospho-β-D-
ribosyl)glycinamide
Phosphate
Adenosine
diphosphate
Hydrogen Ion
10-formyl-
tetrahydrofolate
mono-L-
glutamate
Hydrogen Ion
tetrahydropteroyl
mono-L-
glutamate
5'-
Phosphoribosyl-
N-
formylglycinamide
Water
L-Glutamine
Adenosine
triphosphate
2- (Formamido)-
N1-(5-
phospho-D-
ribosyl)acetamidine
L-Glutamic acid
Phosphate
Adenosine
diphosphate
Hydrogen Ion
Adenosine
triphosphate
5-
Aminoimidazole
ribonucleotide
Phosphate
Adenosine
diphosphate
Hydrogen Ion
S-
Adenosylmethionine
Hydrogen Ion
Carbon monoxide
Formic acid
L-Methionine
5'-
Deoxyadenosine
4-amino-2-
methyl-5-
phosphomethylpyrimidine
Adenosine
triphosphate
Adenosine
diphosphate
4-amino-2-
methyl-5-
diphosphomethylpyrimidine
2-((2R,5Z)-2-
Carboxy-4-
methylthiazol-
5(2H)-
ylidene)ethyl
phosphate
Hydrogen Ion
Carbon dioxide
Pyrophosphate
Thiamine
monophosphate
Adenosine
triphosphate
Adenosine
diphosphate
Thiamine
pyrophosphate
Adenosine
triphosphate
Formic acid
Adenosine
diphosphate
Phosphate
Hydrogen Ion