 
          Loading Pathway... 
Error: Pathway image not found.
Hide 
    Pathway Description
      Pyruvate Decarboxylation to Acetyl-CoA
Escherichia coli
          Metabolic Pathway
          
        
          The multi-enzyme complex catalyze three reactions that constitute a cycle, which is an essential source of acetyl-CoA. Pyruvate dehydrogenase E1 and dihydrolipoyllysine-residue acetyltransferase catalyzes pyruvic acid to acetyl-CoA and CO2. Acetyl-CoA is required for the TCA cycle. Lipoamide dehydrogenase reduces NAD+ to NADH. 
        
      References
      
      Pyruvate Decarboxylation to Acetyl-CoA References
de Kok A, Hengeveld AF, Martin A, Westphal AH: The pyruvate dehydrogenase multi-enzyme complex from Gram-negative bacteria. Biochim Biophys Acta. 1998 Jun 29;1385(2):353-66.
                  Pubmed: 9655933
              Highlighted elements will appear in red.
        
          
          
        
      
      Highlight Compounds
      Highlight Proteins
      Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
        
          
          
        
      
      Visualize Compound Data
      Visualize Protein Data
      Downloads
      
    Settings