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Pathway Description
D-Serine Degradation
Escherichia coli
Metabolic Pathway
The degradation of D-serine begins with the transport of D-serine into the cytosol through a cycA. Once in the cytosol D-serine reacts with ammonia-lyase resulting in the release of a hydrogen ion, water and a 2-aminoprop-2-enoate. This compound in turn reacts spontaneously to produces 2-iminipropanoate. This compound in turn reacts with water and hydrogen ion spontaneously resulting in the release of ammonium and apyruvate.
References
D-Serine Degradation References
Anfora AT, Haugen BJ, Roesch P, Redford P, Welch RA: Roles of serine accumulation and catabolism in the colonization of the murine urinary tract by Escherichia coli CFT073. Infect Immun. 2007 Nov;75(11):5298-304. doi: 10.1128/IAI.00652-07. Epub 2007 Sep 4.
Pubmed: 17785472
Bloom FR, McFall E: Isolation and characterization of D-serine deaminase constitutive mutants by utilization of D-serine as sole carbon or nitrogen source. J Bacteriol. 1975 Mar;121(3):1078-84.
Pubmed: 1090588
Cosloy SD, McFall E: Metabolism of D-serine in Escherichia coli K-12: mechanism of growth inhibition. J Bacteriol. 1973 May;114(2):685-94.
Pubmed: 4574697
MCFALL E: GENETIC STRUCTURE OF THE D-SERINE DEAMINASE SYSTEM OF ESCHERICHIA COLI. J Mol Biol. 1964 Sep;9:746-53.
Pubmed: 14216615
MCFALL E: PLEIOTROPIC MUTATIONS IN THE D-SERINE DEAMINASE SYSTEM OF ESCHERICHIA COLI. J Mol Biol. 1964 Sep;9:754-62.
Pubmed: 14216616
Moritz RL, Welch RA: The Escherichia coli argW-dsdCXA genetic island is highly variable, and E. coli K1 strains commonly possess two copies of dsdCXA. J Clin Microbiol. 2006 Nov;44(11):4038-48. doi: 10.1128/JCM.01172-06.
Pubmed: 17088369
PARDEE AB, PRESTIDGE LS: Induced formation of serine and threonine deaminases by Escherichia coli. J Bacteriol. 1955 Dec;70(6):667-74.
Pubmed: 13271312
Roesch PL, Redford P, Batchelet S, Moritz RL, Pellett S, Haugen BJ, Blattner FR, Welch RA: Uropathogenic Escherichia coli use d-serine deaminase to modulate infection of the murine urinary tract. Mol Microbiol. 2003 Jul;49(1):55-67.
Pubmed: 12823810
Sakinc T, Michalski N, Kleine B, Gatermann SG: The uropathogenic species Staphylococcus saprophyticus tolerates a high concentration of D-serine. FEMS Microbiol Lett. 2009 Oct;299(1):60-4. doi: 10.1111/j.1574-6968.2009.01731.x. Epub 2009 Jul 17.
Pubmed: 19674114
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