PathWhiz

Pathway Description

BaeSR Two-Component Signal Transduction System

Escherichia coli

Protein Pathway

In E.coli K-12, two component systems (TCSs) are responsible for sensing and response to changes in environmental conditions. Sensor kinase response environmental signals by auto-phosphorylate on membrane, which transfer a phosphoryl group to a response regulator (RR) for activation. Signal transduction histidine-protein kinase (BaeS) is sensor kinase and transcriptional regulatory protein (BaeR) is the response regulator in the TCSs. BaeR overexpression may lead to greater resistance to novobiocin and deoxycholate.

References

BaeSR Two-Component Signal Transduction System References

Baranova N, Nikaido H: The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. J Bacteriol. 2002 Aug;184(15):4168-76.

Pubmed: 12107134

Highlighted elements will appear in red.

Highlight Compounds

	Adenosine diphosphate
	Adenosine triphosphate
	Phosphate

Highlight Proteins

	Signal transduction histidine-protein kinase BaeS
	Transcriptional regulatory protein BaeR

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