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Pathway Description
Mannose Metabolism
Saccharomyces cerevisiae
Metabolic Pathway
Mannose is metabolized through the phosphorylation of mannose by a mannokinase resulting in a D-mannopyranose 6-phosphate. The latter compound is isomerized into a B-D-fructofuranose 6-phosphate which can either be incorporated into glycolysis or it can be further be metabolized into a mannose 1-phosphate through a phosphomannomutase. Mannose 1-phosphate then react with a gdp and a hydrogen ion to produce GDP-alpha-D-mannose
References
Mannose Metabolism References
Albright CF, Orlean P, Robbins PW: A 13-amino acid peptide in three yeast glycosyltransferases may be involved in dolichol recognition. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7366-9.
Pubmed: 2678101
Babczinski P, Haselbeck A, Tanner W: Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme. Eur J Biochem. 1980 Apr;105(3):509-15.
Pubmed: 6989607
Lobo Z, Maitra PK: Genetics of yeast hexokinase. Genetics. 1977 Aug;86(4):727-44.
Pubmed: 17248750
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