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Mitochondria Homocitrate synthase, mitochondrial Homocitrate synthase, cytosolic isozyme Homoaconitase, mitochondrial Homoisocitrate dehydrogenase, mitochondrial L-2- aminoadipate reductase L-2- aminoadipate reductase Saccharopine dehydrogenase [NADP(+), L-glutamate- forming] Saccharopine dehydrogenase [NAD(+), L-lysine- forming] Oxoglutaric acid Acetyl-CoA H2O CoA Homocitric acid H+ Oxoglutaric acid Acetyl-CoA H2O Homocitric acid CoA H+ H2O cis- homoaconitate H2O (1R,2S)- homoisocitrate NAD CO2 NADH Oxoadipic acid L-Glutamic acid Oxoglutaric acid Aminoadipic acid ATP PPi AMP H+ NADPH NADP Allysine NADPH L-Glutamic acid H+ H2O NADP Saccharopine NAD H2O NADH H+ Oxoglutaric acid L-Lysine H2O holo-[LYS2 peptidyl- carrier- protein] L-2- aminoadipyl- [LYS2 peptidyl- carrier- protein] holo-[LYS2 peptidyl- carrier- protein]
Mitochondria LYS21 LYS20 LYS4 LYS12 LYS2 LYS2 LYS9 LYS1 Oxoglutaric acid Acetyl-CoA Water Coenzyme A Homocitric acid Hydrogen Ion Oxoglutaric acid Acetyl-CoA Water Homocitric acid Coenzyme A Hydrogen Ion Water cis- homoaconitate Water (1R,2S)- homoisocitrate NAD Carbon dioxide NADH Oxoadipic acid L-Glutamic acid Oxoglutaric acid Aminoadipic acid Adenosine triphosphate Pyrophosphate Adenosine monophosphate Hydrogen Ion NADPH NADP Allysine NADPH L-Glutamic acid Hydrogen Ion Water NADP Saccharopine NAD Water NADH Hydrogen Ion Oxoglutaric acid L-Lysine Water holo-[LYS2 peptidyl- carrier- protein] L-2- aminoadipyl- [LYS2 peptidyl- carrier- protein] holo-[LYS2 peptidyl- carrier- protein]