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Anthranilate
synthase
component 1
Multifunctional
tryptophan
biosynthesis
protein
Anthranilate
phosphoribosyltransferase
N-(5'-
phosphoribosyl)anthranilate
isomerase
Tryptophan
synthase
Kynurenine
formamidase
Kynurenine
3-monooxygenase
Kynureninase
Kynureninase
3-
hydroxyanthranilate
3,4-dioxygenase
aromatic amino
acid
aminotransferase
II
Pyruvate
decarboxylase
isozyme 1
pyruvate
decarboxylase 2
Pyruvate
decarboxylase
isozyme 3
alcohol
dehydrogenase
subunit I
alcohol
dehydrogenase
subunit 2
Tryptophan
synthase
Indoleamine
2,3-dioxygenase
Aromatic/aminoadipate
aminotransferase
1
Chorismate
L-Glutamine
Pyruvic acid
L-Glutamic acid
H
+
2-Aminobenzoic
acid
Phosphoribosyl
pyrophosphate
PP
i
N-(5-
phosphoribosyl)-
anthranilate
1-(2-
carboxyphenylamino)-
1-deoxy-D-
ribulose
5-phosphate
H
+
H
2
O
CO
2
Indoleglycerol
phosphate
Indole
D-
Glyceraldehyde
3-phosphate
N'-
Formylkynurenine
H
2
O
Formic acid
H
+
L-Kynurenine
H
+
NADPH
O
2
3-hydroxy-L-
kynurenine
NADP
H
2
O
H
2
O
H
+
L-Alanine
2-Aminobenzoic
acid
H
2
O
L-Alanine
H
+
3-
Hydroxyanthranilic
acid
O
2
H
+
2-Amino-3-
carboxymuconic
acid
semialdehyde
L-Tryptophan
2-Oxo-3-
phenylpropanoic
acid (Mixture
oxo and keto)
indole-3-
pyruvate
L-Phenylalanine
H
+
Indoleacetaldehyde
CO
2
NADH
H
+
NAD
Tryptophol
L-Serine
H
2
O
O
2
Oxoglutaric
acid
L-Glutamic acid