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UDP-L-Ara4N
formyltransferase
/ UDP-GlcA
C-4"-
decarboxylase
dihydrofolate
reductase
dihydrofolate
reductase
Phosphoribosylaminoimidazole
carboxylase
formyltetrahydrofolate
hydrolase
Phosphoribosylaminoimidazole
carboxylase
Bifunctional
purine
biosynthesis
protein ADE17
glycine
hydroxymethyltransferase
methionine
synthase
dihydrofolate
reductase
methylenetetrahydrofolate
reductase
[NAD(P)H]
Thymidylate
synthase
Aminomethyltransferase
10-
formyltetrahydrofolate:L-
methionyl-
tRNA(fMet) N-
formyltransferase
bifunctional
5,10-
methylene-
tetrahydrofolate
dehydrogenase
Aminomethyltransferase
bifunctional
5,10-
methylene-
tetrahydrofolate
dehydrogenase
Dihydrofolic
acid
10-
Formyltetrahydrofolate
4-Amino-4-
deoxy-L-
arabinose
Tetrahydrofolate
UDP-4-Deoxy-
4-formamido-
β-L-arabinose
NADP
Folic acid
NADPH
H
+
NADPH
H
+
Tetrahydrofolic
acid
NADP
5'-
phosphoribosyl-
a-N-
formylglycineamidine
H
2
O
Glycineamideribotide
5,10-
Methenyltetrahydrofolic
acid
Formic acid
H
2
O
5'-
Phosphoribosyl-
N-
formylglycinamide
Glycineamideribotide
FAICAR
1-(5'-
Phosphoribosyl)-
5-amino-4-
imidazolecarboxamide
L-Serine
5,10-
Methylene-THF
Glycine
H
2
O
5-
Methyltetrahydrofolic
acid
Homocysteine
L-Methionine
NADPH
H
+
NADP
NADPH
H
+
NADP
5-Thymidylic
acid
dUMP
NH
3
NADPH
NADP
H
2
O
N5-Formyl-THF
H
+
H
2
O
S-
Aminomethyldihydrolipoylprotein;
dihydrolipoylprotein
N-
formylmethionyl-
tRNA(fMet)
L-Methionyl-
tRNA(Met)
Folate
Biosynthesis
Unknown
Unknown
Unknown
ADE2
Unknown
ADE2
ADE17
Unknown
Unknown
Unknown
Unknown
CDC21
Unknown
Unknown
Unknown
Unknown
Unknown
Dihydrofolic
acid
10-
Formyltetrahydrofolate
4-Amino-4-
deoxy-L-
arabinose
Tetrahydrofolate
UDP-4-Deoxy-
4-formamido-
β-L-arabinose
NADP
Folic acid
NADPH
Hydrogen Ion
NADPH
Hydrogen Ion
Tetrahydrofolic
acid
NADP
5'-
phosphoribosyl-
a-N-
formylglycineamidine
Water
Glycineamideribotide
5,10-
Methenyltetrahydrofolic
acid
Formic acid
Water
5'-
Phosphoribosyl-
N-
formylglycinamide
Glycineamideribotide
FAICAR
1-(5'-
Phosphoribosyl)-
5-amino-4-
imidazolecarboxamide
L-Serine
5,10-
Methylene-THF
Glycine
Water
5-
Methyltetrahydrofolic
acid
Homocysteine
L-Methionine
NADPH
Hydrogen Ion
NADP
NADPH
Hydrogen Ion
NADP
5-Thymidylic
acid
dUMP
Ammonia
NADPH
NADP
Water
N5-Formyl-THF
Hydrogen Ion
Water
S-
Aminomethyldihydrolipoylprotein;
dihydrolipoylprotein
N-
formylmethionyl-
tRNA(fMet)
L-
Methionyl-
tRNA(Met)
Folate
Biosynthesis