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Endoplasmic Reticulum
Unknown
Serine
palmitoyltransferase
1
3-
ketodihydrosphingosine
reductase
Sphingosine
kinase 2
Sphingosine-1-
phosphate
phosphatase 2
Lipid phosphate
phosphohydrolase
1
Sphingosine-1-
phosphate lyase 1
Sphingosine-1-
phosphate lyase 1
Sphingosine
kinase 2
Sphingosine-1-
phosphate
phosphatase 2
Lipid phosphate
phosphohydrolase
1
Phosphatidylcholine:ceramide
cholinephosphotransferase
1
Ectonucleotide
pyrophosphatase/phosphodiesterase
family member 7
Acyl-CoA-
dependent
ceramide synthase
Acyl-CoA-
dependent
ceramide synthase
2
sphinganine
C4-monooxygenase
Alkaline
ceramidase 3
L-Serine
Palmitoyl-CoA
3-
Dehydrosphinganine
Sphinganine
NADPH
NADP
ATP
ADP
Sphinganine
1-phosphate
ADP
ATP
P
i
O-
Phosphoethanolamine
Sphingosine
1-phosphate
Sphingosine
ATP
ADP
ADP
ATP
P
i
Ceramide
(d18:1/18:0)
SM(d18:1/18:0)
Succinyl-CoA
Sphinganine
Dihydroceramide
CoA
Ferrocytochrome
O
2
H
+
Phytosphingosine
ferricytochrome c
H
2
O
Pyridoxal
5'-phosphate
Magnesium
Pyridoxal
5'-phosphate
Pyridoxal
5'-phosphate
Magnesium
Zinc
Calcium
Glycine and
Serine
Metabolism
Intracellular space
Endoplasmic Reticulum
Golgi complex
Endoplasmic Reticulum
LAG1
LAC1
SUR2
Ser
COA16:0
3-DHPG
d18:0
NADPH
NADP
ATP
ADP
Sphg-1P
ADP
ATP
P
i
Ethamp
S1P
Sphingo
ATP
ADP
ADP
ATP
P
i
Ceram18
Sphingo
Suc-CoA
d18:0
DHCeram
CoA
Ferrocy
O
2
H
+
Phytosp
FrcytcC
H
2
O
Pyr-5'P
Mg2+
Pyr-5'P
Pyr-5'P
Mg2+
Zinc
Ca2+
PW122420
Intracellular space
Endoplasmic Reticulum
Golgi complex