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Acetyl-CoA acetyltransferase, cytosolic Mevalonate kinase Phosphomevalonate kinase Diphosphomevalonate decarboxylase Isopentenyl- diphosphate Delta-isomerase 1 Farnesyl pyrophosphate synthase Geranylgeranyl pyrophosphate synthase Farnesyl pyrophosphate synthase Geranylgeranyl pyrophosphate synthase 3-hydroxy-3- methylglutaryl- coenzyme A reductase Hexaprenyl pyrophosphate synthase, mitochondrial ditrans,polycis- polyprenyl diphosphate synthase RER2 dehydrodolichyl diphosphate syntase complex subunit NUS1 ditrans,polycis- polyprenyl diphosphate synthase SRT1 Hydroxymethylglutaryl- CoA synthase Geranylgeranyl pyrophosphate synthase Acetoacetyl-CoA Acetyl-CoA CoA Mevalonic acid ATP Mevalonic acid-5P ADP ATP ADP (S)-5- Diphosphomevalonic acid ATP ADP Pi Isopentenyl pyrophosphate CO2 Dimethylallylpyrophosphate Geranyl-PP PPi Farnesyl pyrophosphate PPi 3-Hydroxy-3- methylglutaryl- CoA NADPH NADP CoA Isopentenyl pyrophosphate All-trans- hexaprenyl diphosphate PPi Isopentenyl pyrophosphate di-trans, poly-cis- polyprenyl diphosphate (C80) PPi H2O CoA Isopentenyl pyrophosphate PPi Geranylgeranyl- PP Magnesium Magnesium Magnesium Magnesium Magnesium Butyrate Metabolism Pyruvate Metabolism Valine, Leucine, and Isoleucine Degradation Tryptophan Metabolism Pyruvate Metabolism Fatty Acid Metabolism Endoplasmic Reticulum Peroxisome Peroxisome Outer membrane Inner membrane
Endoplasmic Reticulum Mitochondria Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown COQ1 RER2 NUS1 SRT1 ERG13 Unknown Acetoacetyl-CoA Acetyl-CoA Coenzyme A Mevalonic acid Adenosine triphosphate Mevalonic acid-5P Adenosine diphosphate Adenosine triphosphate Adenosine diphosphate (S)-5- Diphosphomevalonic acid Adenosine triphosphate Adenosine diphosphate Phosphate Isopentenyl pyrophosphate Carbon dioxide Dimethylallylpyrophosphate Geranyl-PP Pyrophosphate Farnesyl pyrophosphate Pyrophosphate 3-Hydroxy-3- methylglutaryl- CoA NADPH NADP Coenzyme A Isopentenyl pyrophosphate All-trans- hexaprenyl diphosphate Pyrophosphate Isopentenyl pyrophosphate di-trans, poly-cis- polyprenyl diphosphate (C80) Pyrophosphate Water Coenzyme A Isopentenyl pyrophosphate Pyrophosphate Geranylgeranyl- PP Butyrate Metabolism Pyruvate Metabolism Valine, Leucine, and Isoleucine Degradation Tryptophan Metabolism Pyruvate Metabolism Fatty Acid Metabolism