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Acetyl-CoA
acetyltransferase,
cytosolic
Mevalonate
kinase
Phosphomevalonate
kinase
Diphosphomevalonate
decarboxylase
Isopentenyl-
diphosphate
Delta-isomerase
1
Farnesyl
pyrophosphate
synthase
Geranylgeranyl
pyrophosphate
synthase
Farnesyl
pyrophosphate
synthase
Geranylgeranyl
pyrophosphate
synthase
3-hydroxy-3-
methylglutaryl-
coenzyme A
reductase
Hexaprenyl
pyrophosphate
synthase,
mitochondrial
ditrans,polycis-
polyprenyl
diphosphate
synthase RER2
dehydrodolichyl
diphosphate
syntase complex
subunit NUS1
ditrans,polycis-
polyprenyl
diphosphate
synthase SRT1
Hydroxymethylglutaryl-
CoA synthase
Geranylgeranyl
pyrophosphate
synthase
Acetoacetyl-CoA
Acetyl-CoA
CoA
Mevalonic acid
ATP
Mevalonic
acid-5P
ADP
ATP
ADP
(S)-5-
Diphosphomevalonic
acid
ATP
ADP
P
i
Isopentenyl
pyrophosphate
CO
2
Dimethylallylpyrophosphate
Geranyl-PP
PP
i
Farnesyl
pyrophosphate
PP
i
3-Hydroxy-3-
methylglutaryl-
CoA
NADPH
NADP
CoA
Isopentenyl
pyrophosphate
All-trans-
hexaprenyl
diphosphate
PP
i
Isopentenyl
pyrophosphate
di-trans,
poly-cis-
polyprenyl
diphosphate
(C80)
PP
i
H
2
O
CoA
Isopentenyl
pyrophosphate
PP
i
Geranylgeranyl-
PP
Magnesium
Magnesium
Magnesium
Magnesium
Magnesium
Butyrate
Metabolism
Pyruvate
Metabolism
Valine,
Leucine, and
Isoleucine
Degradation
Tryptophan
Metabolism
Pyruvate
Metabolism
Fatty Acid
Metabolism
Endoplasmic Reticulum
Peroxisome
Peroxisome
Outer membrane
Inner membrane
Endoplasmic Reticulum
Mitochondria
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
COQ1
RER2
NUS1
SRT1
ERG13
Unknown
Acetoacetyl-CoA
Acetyl-CoA
Coenzyme A
Mevalonic acid
Adenosine
triphosphate
Mevalonic
acid-5P
Adenosine
diphosphate
Adenosine
triphosphate
Adenosine
diphosphate
(S)-5-
Diphosphomevalonic
acid
Adenosine
triphosphate
Adenosine
diphosphate
Phosphate
Isopentenyl
pyrophosphate
Carbon dioxide
Dimethylallylpyrophosphate
Geranyl-PP
Pyrophosphate
Farnesyl
pyrophosphate
Pyrophosphate
3-Hydroxy-3-
methylglutaryl-
CoA
NADPH
NADP
Coenzyme A
Isopentenyl
pyrophosphate
All-trans-
hexaprenyl
diphosphate
Pyrophosphate
Isopentenyl
pyrophosphate
di-trans,
poly-cis-
polyprenyl
diphosphate
(C80)
Pyrophosphate
Water
Coenzyme A
Isopentenyl
pyrophosphate
Pyrophosphate
Geranylgeranyl-
PP
Butyrate
Metabolism
Pyruvate
Metabolism
Valine,
Leucine, and
Isoleucine
Degradation
Tryptophan
Metabolism
Pyruvate
Metabolism
Fatty Acid
Metabolism