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hydroxymethylpyrimidine/phosphomethylpyrimidine
kinase THI20
hydroxymethylpyrimidine/phosphomethylpyrimidine
kinase THI21
hydroxymethylpyrimidine/phosphomethylpyrimidine
kinase THI20
hydroxymethylpyrimidine/phosphomethylpyrimidine
kinase THI21
hydroxymethylpyrimidine/phosphomethylpyrimidine
kinase THI20
Thiamine
biosynthetic
bifunctional
enzyme
Thiamine
biosynthetic
bifunctional
enzyme
hydroxymethylpyrimidine/phosphomethylpyrimidine
kinase THI20
acid phosphatase
PHO12
Acid phosphatase
PHO11
Repressible acid
phosphatase
acid phosphatase
PHO3
Thiamine
pyrophosphokinase
ATP
4-amino-2-
methyl-5-
phosphomethylpyrimidine
ADP
2-Methyl-4-
amino-5-
hydroxymethylpyrimidine
diphosphate
ATP
4-Amino-5-
hydroxymethyl- 2-
methylpyrimidine
ADP
pyrithiamine
H
2
O
2-(2-
methylpyridin-
3-yl)ethanol
H
+
4-methyl-5-(2-
phosphonooxyethyl)thiazole
PP
i
Thiamine
monophosphate
4-methyl-5-(β-
hydroxyethyl)thiazole
ATP
H
+
ADP
oxythiamine
H
2
O
H
+
5-
(hydroxymethyl)-
2-methyl-4(1H)-
pyrimidinone
H
2
O
Thiamine
P
i
ATP
H
+
AMP
Thiamine
pyrophosphate
oxidized
electron
acceptor
reduced
electron
acceptor
THI20
THI21
THI20
THI21
THI20
THI6
THI6
THI20
PHO12
PHO11
PHO5
PHO3
THI80
Adenosine
triphosphate
4-amino-2-
methyl-5-
phosphomethylpyrimidine
Adenosine
diphosphate
2-Methyl-4-
amino-5-
hydroxymethylpyrimidine
diphosphate
Adenosine
triphosphate
4-Amino-5-
hydroxymethyl- 2-
methylpyrimidine
Adenosine
diphosphate
pyrithiamine
Water
2-(2-
methylpyridin-
3-yl)ethanol
Hydrogen Ion
4-methyl-5-(2-
phosphonooxyethyl)thiazole
Pyrophosphate
Thiamine
monophosphate
4-methyl-5-(β-
hydroxyethyl)thiazole
Adenosine
triphosphate
Hydrogen Ion
Adenosine
diphosphate
oxythiamine
Water
Hydrogen Ion
5-
(hydroxymethyl)-
2-methyl-4(1H)-
pyrimidinone
Water
Thiamine
Phosphate
Adenosine
triphosphate
Hydrogen Ion
Adenosine
monophosphate
Thiamine
pyrophosphate
oxidized electron
acceptor
reduced electron
acceptor