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Pyruvate kinase PKM Pyruvate kinase isozymes R/L Solute carrier family 2, facilitated glucose transporter member 2 Mitochondrial pyruvate carrier 1 Monocarboxylate transporter 1 Neutral amino acid transporter B(0) Mitochondrial citrate transport protein Zinc transporter ZIP1 Zinc transporter ZIP2 Zinc transporter ZIP3 Zinc transporter ZIP4 Zinc transporter ZIP5 Zinc transporter ZIP8 Zinc transporter ZIP10 Zinc transporter ZIP14 Hexokinase-2 Glucose-6- phosphate isomerase 6- phosphofructokinase, liver type Fructose- bisphosphate aldolase B Glyceraldehyde- 3-phosphate dehydrogenase Phosphoglycerate kinase 1 Phosphoglycerate mutase 2 Alpha-enolase Pyruvate carboxylase, mitochondrial Pyruvate dehydrogenase complex Citrate synthase, mitochondrial L-lactate dehydrogenase A-like 6A Aconitate hydratase, mitochondrial Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Oxoglutarate dehydrogenase complex Succinyl-CoA ligase Succinate dehydrogenase Fumarate hydratase, mitochondrial Malate dehydrogenase, cytoplasmic Glutamate dehydrogenase 1, mitochondrial Glutaminase liver isoform, mitochondrial Cytoplasmic aconitate hydratase Isocitrate dehydrogenase [NADP] cytoplasmic D-3- phosphoglycerate dehydrogenase Phosphoserine aminotransferase Phosphoserine phosphatase Serine hydroxymethyltransferase, cytosolic Glycine N- methyltransferase D-Glucose D-Glucose Pyruvic acid Pyruvic acid L-Lactic acid L-Glutamine L-Glutamine L-Glutamine Citric acid Citric acid Zinc (II) ion Zinc (II) ion ATP Glucose 6-phosphate ADP Fructose 6-phosphate ATP Fructose 1,6-bisphosphate ADP D-Glyceraldehyde 3-phosphate NAD Glyceric acid 1,3-biphosphate NADH ADP 3- Phosphoglyceric acid ATP 2-Phospho-D- glyceric acid Phosphoenolpyruvic acid H 2 O ATP ADP ATP HCO 3 - ADP P i Oxalacetic acid CoA NAD Acetyl-CoA CO 2 NADH H 2 O CoA NAD NADH Isocitric acid NAD Oxoglutaric acid CO 2 NADH NAD CoA Succinyl-CoA NADH CO 2 P i GDP Succinic acid CoA GTP Q FAD Fumaric acid QH 2 FADH 2 L-Malic acid H 2 O NAD NADH L-Glutamic acid H 2 O NH 3 H 2 O NH 3 Isocitric acid NADP Oxoglutaric acid NADPH CO 2 NAD Phosphohydroxypyruvic acid NADH L-Glutamic acid Phosphoserine Oxoglutaric acid H 2 O L-Serine P i Tetrahydrofolic acid Glycine 5,10- Methylene-THF H 2 O Sarcosine S- Adenosylhomocysteine S- Adenosylmethionine Magnesium Potassium Magnesium Magnesium Biotin Manganese Thiamine pyrophosphate Lipoamide FAD 4Fe-4S Magnesium Thiamine pyrophosphate Lipoamide FAD 4Fe-4S Magnesium Pyridoxal 5'-phosphate Magnesium Pyridoxal 5'-phosphate L-Lactic acid Lactate shuttle Citric Acid Cycle Inner Mitochondrial Membrane Outer Mitochondrial Membrane Mitochondrion Cytosol Glycolysis Phosphoenolpyruvic acid Pyruvic acid L-Lactic acid 2-Phospho-D-glyceric acid 3-Phosphoglyceric acid Glyceric acid 1,3-biphosphate D-Glyceraldehyde 3-phosphate Fructose 6-phosphate Fructose 1,6-bisphosphate Pyruvate kinase PKLR L-lactate dehydrogenase Pyruvate kinase PKM
Mitochondria PKM PKLR SLC2A2 MPC1 SLC16A1 SLC1A5 Unknown SLC39A1 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A8 SLC39A10 SLC39A14 HK2 GPI PFKL ALDOB GAPDH PGK1 PGAM2 ENO1 PC PDHA1 CS LDHAL6A ACO2 IDH3A IDH3B IDH3G OGDH SUCLG1 SUCLG2 SDHA SDHB SDHC SDHD FH MDH1 GLUD1 GLS2 ACO1 IDH1 PHGDH PSAT1 PSPH SHMT1 GNMT D-Glucose D-Glucose Pyruvic acid Pyruvic acid L-Lactic acid L-Glutamine L-Glutamine L-Glutamine Citric acid Citric acid Zinc (II) ion Zinc (II) ion Adenosine triphosphate Glucose 6-phosphate Adenosine diphosphate Fructose 6-phosphate Adenosine triphosphate Fructose 1,6- bisphosphate Adenosine diphosphate D- Glyceraldehyde 3-phosphate NAD Glyceric acid 1,3-biphosphate NADH Adenosine diphosphate 3- Phosphoglyceric acid Adenosine triphosphate 2-Phospho-D- glyceric acid Phosphoenolpyruvic acid Water Adenosine triphosphate Adenosine diphosphate Adenosine triphosphate Hydrogen carbonate Adenosine diphosphate Phosphate Oxalacetic acid Coenzyme A NAD Acetyl-CoA Carbon dioxide NADH Water Coenzyme A NAD NADH Isocitric acid NAD Oxoglutaric acid Carbon dioxide NADH NAD Coenzyme A Succinyl-CoA NADH Carbon dioxide Phosphate Guanosine diphosphate Succinic acid Coenzyme A Guanosine triphosphate Coenzyme Q10 FAD Fumaric acid QH(2) FADH L-Malic acid Water NAD NADH L-Glutamic acid Water Ammonia Water Ammonia Isocitric acid NADP Oxoglutaric acid NADPH Carbon dioxide NAD Phosphohydroxypyruvic acid NADH L-Glutamic acid Phosphoserine Oxoglutaric acid Water L-Serine Phosphate Tetrahydrofolic acid Glycine 5,10- Methylene-THF Water Sarcosine S- Adenosylhomocysteine S- Adenosylmethionine L-Lactic acid