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Pathway Description
TOR Signalling Pathway: Rapamycin-Based Repression
Saccharomyces cerevisiae
Protein Pathway
The TOR signalling pathway is responsible for the cellular reactions towards nutrient and energy availability and hypoxia/stress.
When TOR1/2 is activated, it activates TAP42 which in turn can inhibit SIT4 . I can also activate TAP41 phosphorylation. The enzyme SIT4 activates the dephosphorylation of TIP41 which in turn inhibits TAP42. The enzyme SIT4 also activates the dephosphorylation of Ure2-Gln3 complex and the
separation of Ure2 and Gln3. Gln3 then gets incorporated into the nucleus resulting in the transcription of GLN1, GLT1,GDH1,GDH2,GAP1,MEP2,DAL3,PUT1 which are incorporated into Nitrogen Utilization
References
TOR Signalling Pathway: Rapamycin-Based Repression References
Beck T, Hall MN: The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature. 1999 Dec 9;402(6762):689-92. doi: 10.1038/45287.
Pubmed: 10604478
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