PathWhiz

Pathway Description

Lysolipid Incorporation into Mitochondria

Saccharomyces cerevisiae

Metabolic Pathway

Lysolipids such as lysophosphatidylethanolamine, lysophosphatidylcholine, lysophosphatidylserine and lysophosphatidylinositol get transported into the cell through a phospholipid ATPase. Once in the cytosol they are incorporated into the mitochondria membrane through a Ale1p transport membrane where phosphatidylcholine is generated.

References

Lysolipid Incorporation into Mitochondria References

Riekhof WR, Wu J, Gijon MA, Zarini S, Murphy RC, Voelker DR: Lysophosphatidylcholine metabolism in Saccharomyces cerevisiae: the role of P-type ATPases in transport and a broad specificity acyltransferase in acylation. J Biol Chem. 2007 Dec 21;282(51):36853-61. doi: 10.1074/jbc.M706718200. Epub 2007 Oct 21.

Pubmed: 17951629

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine diphosphate
		Adenosine triphosphate
		Hydrogen Ion
		Lyso-PI(0:0/14:0)
		Lyso-PI(14:0/0:0)
		Lyso-PS(0:0/14:0)
		Lyso-PS(14:0/0:0)
		LysoPC(14:0/0:0)
		LysoPE(14:0/0:0)
		PC(14:0/14:0)
		PE(14:0/14:0)
		PE-NMe(14:0/14:0)
		PE-NMe2(14:0/14:0)
		Phosphate
		PI(14:0/14:0)
		PS(14:0/14:0)
		S-Adenosylhomocysteine
		S-Adenosylmethionine
		Water

Visualize Protein Data

		Ale1p acyltransferase
		Alkylphosphocholine resistance protein LEM3
		Phosphatidyl-N-methylethanolamine N-methyltransferase
		Phosphatidylethanolamine N-methyltransferase
		Phospholipid-transporting ATPase DNF1
		Phospholipid-transporting ATPase DNF2

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