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Pathway Description
Phytate Biosynthesis
Arabidopsis thaliana
Metabolic Pathway
Phytate biosynthesis is a pathway that occurs in the cytosol by which myo-inositol becomes D-myo-inositol (1,3,4)-trisphosphate becomes phytate, the principal storage form of phosphorus in many plant tissues . First, myo-inositol-1,3,4-trisphosphate 5/6-kinase uses ATP to catalyze the conversion of D-myo-inositol (1,3,4)-trisphosphate into either D-myo-inositol (1,3,4,6)-tetrakisphosphate or D-myo-inositol (1,3,4,5)-tetrakisphosphate. It requires magnesium ion as a cofactor. Second, inositol polyphosphate multiple-kinase uses ATP to catalyze the conversion of either D-myo-inositol (1,3,4,6)-tetrakisphosphate or D-myo-inositol (1,3,4,5)-tetrakisphosphate into D-myo-inositol 1,3,4,5,6-pentakisphosphate. Third, polyphosphate 2-kinase uses ATP to catalyze the conversion of D-myo-inositol 1,3,4,5,6-pentakisphosphate into phytate. It requires zinc ion as a cofactor.
References
Phytate Biosynthesis References
Sweetman D, Johnson S, Caddick SE, Hanke DE, Brearley CA: Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1). Biochem J. 2006 Feb 15;394(Pt 1):95-103. doi: 10.1042/BJ20051331.
Pubmed: 16223361
Stevenson-Paulik J, Odom AR, York JD: Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases. J Biol Chem. 2002 Nov 8;277(45):42711-8. doi: 10.1074/jbc.M209112200. Epub 2002 Sep 10.
Pubmed: 12226109
Wilson MP, Majerus PW: Characterization of a cDNA encoding Arabidopsis thaliana inositol 1,3,4-trisphosphate 5/6-kinase. Biochem Biophys Res Commun. 1997 Mar 27;232(3):678-81. doi: 10.1006/bbrc.1997.6355.
Pubmed: 9126335
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