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Pathway Description
Ascorbate Biosynthesis
Mus musculus
Metabolic Pathway
L-Ascorbate commonly known as vitamin C is a reducing agent and cofactor in reactions catalyzed by copper-dependent monooxygenases and iron-dependent dioxygenases. It is synthesized from direct hydrolysis of UDP-α-D-glucuronate by enzymes bound to the endoplasmic reticulum membrane. It can be biosynthesized in many plants and bacteria and used as vitamin supplements. Other common uses include being an additive for beverage production and live stock feed. Without sufficient levels of L-ascorbate disorders such as scurvy may develop.
References
Ascorbate Biosynthesis References
Tulsiani DR, Touster: Resolution and partial characterization of two aldehyde reductases of mammalian liver. J Biol Chem. 1977 Apr 25;252(8):2545-50.
Pubmed: 15991
Linster CL, Van Schaftingen E: Vitamin C. Biosynthesis, recycling and degradation in mammals. FEBS J. 2007 Jan;274(1):1-22. doi: 10.1111/j.1742-4658.2006.05607.x.
Pubmed: 17222174
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