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Alcohol dehydrogenase [NADP(+)] Regucalcin L-gulonolactone oxidase Uridine diphosphate glucuronic acid H2O D- glucopyranuronate H+ Uridine 5'-diphosphate aldehydo-D- glucuronate NADPH H+ Gulonic acid NADP H+ L-Gulonolactone H2O O2 L-xylo- Hexulonolactone H2O2 Ascorbic acid H+ Zinc (II) ion Manganese Calcium Magnesium FAD UDP- glucuronidase UDP-α-D- glucuronate Biosynthesis Endoplasmic Reticulum Cytoplasm
Akr1a1 Rgn Gulo UDPGlcA H2O D-Gpyra H+ UDP AlDgluc NADPH H+ GulnA NADP H+ L-Gul H2O O2 LXH H2O2 VitC H+ Zinc Mn2+ Ca2+ Mg2+ FAD UG U-α-D-g Endoplasmic Reticulum Cytoplasm
Endoplasmic Reticulum Akr1a1 Rgn Gulo UDPGlcA H2O D-Gpyra H+ UDP AlDgluc NADPH H+ GulnA NADP H+ L-Gul H2O O2 LXH H2O2 VitC H+ UG U-α-D-g