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Proto-oncogene FRAT1 Proto-oncogene Wnt-1 Wnt inhibitory factor 1 Dickkopf- related protein 1 Segment polarity protein dishevelled homolog DVL-1 Casein kinase I isoform alpha Casein kinase I isoform delta Casein kinase II subunit alpha Segment polarity protein dishevelled homolog DVL-1 Protein naked cuticle homolog 1 Serine/threonine- protein phosphatase 2A catalytic subunit alpha isoform Axin-1 Adenomatous polyposis coli protein Catenin beta-1 Mitogen- activated protein kinase kinase kinase 7 TGF-beta- activated kinase 1 and MAP3K7-binding protein 1 Serine/threonine- protein kinase NLK C-terminal- binding protein 1 CREB-binding protein Hepatocyte nuclear factor 1-alpha Transducin-like enhancer protein 1 C-terminal- binding protein 1 CREB-binding protein Hepatocyte nuclear factor 1-alpha Transducin-like enhancer protein 1 Catenin beta-1 Mothers against decapentaplegic homolog 4 Histone deacetylase 1 Myc proto-oncogene protein G1/S-specific cyclin-D1 Peroxisome proliferator- activated receptor delta Catenin beta-1 Catenin beta-1 Axin-1 Catenin beta-1 F-box/WD repeat- containing protein 1A Proto-oncogene Wnt-1 Glycogen synthase kinase-3 beta Axin-1 Adenomatous polyposis coli protein Catenin beta-1 Catenin beta-1 F-box/WD repeat- containing protein 1A Frizzled-10 Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Frizzled-9 Ub Ub Ub Translocates Ub Ub Ub Ub Ub Ub Proteasome Frizzled-8 Frizzled-7 Frizzled-6 Frizzled-5 Ubiquitin Pathway Frizzled-4 Frizzled-3 Frizzled-2 Frizzled-1 Extracellular Cytoplasm Nucleus
Lysosome FRAT1 WNT1 WIF1 DKK1 DVL1 CSNK1A1 CSNK1D CSNK2A1 DVL1 NKD1 PPP2CA AXIN1 APC CTNNB1 MAP3K7 TAB1 NLK CTBP1 CREBBP HNF1A TLE1 CTBP1 CREBBP HNF1A TLE1 CTNNB1 SMAD4 HDAC1 MYC CCND1 PPARD CTNNB1 CTNNB1 AXIN1 CTNNB1 BTRC WNT1 GSK3B AXIN1 APC CTNNB1 CTNNB1 BTRC FZD10 Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate FZD9 Ub Ub Ub Translocates Ub Ub Ub Ub Ub Ub Proteasome FZD8 FZD7 FZD6 FZD5 Ubiquitin Pathway FZD4 FZD3 FZD2 FZD1
FRAT1 WNT1 WIF1 DKK1 DVL1 CSNK1A1 CSNK1D CSNK2A1 DVL1 NKD1 PPP2CA AXIN1 APC CTNNB1 MAP3K7 TAB1 NLK CTBP1 CREBBP HNF1A TLE1 CTBP1 CREBBP HNF1A TLE1 CTNNB1 SMAD4 HDAC1 MYC CCND1 PPARD CTNNB1 CTNNB1 AXIN1 CTNNB1 BTRC WNT1 GSK3B AXIN1 APC CTNNB1 CTNNB1 BTRC FZD10 Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi FZD9 Ub Ub Ub Translo Ub Ub Ub Ub Ub Ub Proteas FZD8 FZD7 FZD6 FZD5 Ubi Pat FZD4 FZD3 FZD2 FZD1 Extracellular Cytoplasm Nucleus
Lysosome FRAT1 WNT1 WIF1 DKK1 DVL1 CSNK1A1 CSNK1D CSNK2A1 DVL1 NKD1 PPP2CA AXIN1 APC CTNNB1 MAP3K7 TAB1 NLK CTBP1 CREBBP HNF1A TLE1 CTBP1 CREBBP HNF1A TLE1 CTNNB1 SMAD4 HDAC1 MYC CCND1 PPARD CTNNB1 CTNNB1 AXIN1 CTNNB1 BTRC WNT1 GSK3B AXIN1 APC CTNNB1 CTNNB1 BTRC FZD10 Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi FZD9 Ub Ub Ub Translo Ub Ub Ub Ub Ub Ub Proteas FZD8 FZD7 FZD6 FZD5 Ubi Pat FZD4 FZD3 FZD2 FZD1