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Prothrombin Prothrombin NAD(P)H dehydrogenase, quinone 1 Vitamin K epoxide reductase complex subunit 1 Prothrombin Vitamin K-dependent gamma- carboxylase Vitamin K1 NADPH Reduced Vitamin K (phylloquinone) NADP Oxidized dithiothreitol Vitamin K1 2,3-epoxide 1,4- Dithiothreitol O2 CO2 H2O Methylmalonic acid Methylmalonic acid FAD Propionic acid Liver Intracellular SPace Extracellular Space Endoplasmic reticulum
Endoplasmic Reticulum F2 F2 NQO1 VKORC1 F2 GGCX Vitamin K1 NADPH Reduced Vitamin K (phylloquinone) NADP Oxidized dithiothreitol Vitamin K1 2,3-epoxide 1,4- Dithiothreitol Oxygen Carbon dioxide Water
F2 F2 NQO1 VKORC1 F2 GGCX VitK1 NADPH ReVitK NADP Oxidith VitKo L-DTT O2 CO2 H2O Isosca Isosca FAD 3:0 Liver Intracellular SPace Extracellular Space Endoplasmic reticulum
Endoplasmic Reticulum F2 F2 NQO1 VKORC1 F2 GGCX VitK1 NADPH ReVitK NADP Oxidith VitKo L-DTT O2 CO2 H2O