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Pathway Description
G-Protein Signaling Through Tubby Proteins
Homo sapiens
Protein Pathway
Tubby protein is a part of a family of proteins called Tubby Like Proteins (TULP) characterized by 260 amino acids that form a helix-filled barrel structure at the carboxylic acid terminal (Tubby domain). Using its Tubby domain to bind phosphatidylinositol 4,5-bisphosphate (PIP2), Tubby proteins are able to localize on the plasma membrane. Through the receptor mediated activation of G-proteins, the enzyme phospholipase C–beta (PLC-beta) hydrolyses PIP2 releasing tubby from the plasma membrane. This triggers protein translocation of tubby to the nucleus allowing tubby to act as a transcription regulator.
References
G-Protein Signaling Through Tubby Proteins References
Santagata S, Boggon TJ, Baird CL, Gomez CA, Zhao J, Shan WS, Myszka DG, Shapiro L: G-protein signaling through tubby proteins. Science. 2001 Jun 15;292(5524):2041-50. doi: 10.1126/science.1061233. Epub 2001 May 24.
Pubmed: 11375483
Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L: Implication of tubby proteins as transcription factors by structure-based functional analysis. Science. 1999 Dec 10;286(5447):2119-25.
Pubmed: 10591637
He W, Ikeda S, Bronson RT, Yan G, Nishina PM, North MA, Naggert JK: GFP-tagged expression and immunohistochemical studies to determine the subcellular localization of the tubby gene family members. Brain Res Mol Brain Res. 2000 Sep 30;81(1-2):109-17.
Pubmed: 11000483
North MA, Naggert JK, Yan Y, Noben-Trauth K, Nishina PM: Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3128-33.
Pubmed: 9096357
Ikeda A, Nishina PM, Naggert JK: The tubby-like proteins, a family with roles in neuronal development and function. J Cell Sci. 2002 Jan 1;115(Pt 1):9-14.
Pubmed: 11801719
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