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Dual specificity mitogen- activated protein kinase kinase 7 Tumor necrosis factor Mitogen- activated protein kinase kinase kinase 1 Mitogen- activated protein kinase kinase kinase kinase 2 TRAF family member- associated NF-kappa-B activator TNF receptor- associated factor 2 Tumor necrosis factor receptor type 1-associated DEATH domain protein Receptor- interacting serine/threonine- protein kinase 1 Death domain- containing protein CRADD Caspase-2 Mitogen- activated protein kinase 14 Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B essential modulator Nuclear factor NF-kappa-B p105 subunit NF-kappa-B inhibitor alpha NF-kappa-B inhibitor alpha Mitogen- activated protein kinase kinase kinase 1 Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B essential modulator Dual specificity mitogen- activated protein kinase kinase 4 Mitogen- activated protein kinase 10 Transcription factor AP-1 Dual specificity mitogen- activated protein kinase kinase 3 Dual specificity mitogen- activated protein kinase kinase 6 Mitogen- activated protein kinase 14 Cyclic AMP-dependent transcription factor ATF-1 Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi NF-κB Tumor necrosis factor receptor superfamily member 1A IKB Ubiquitination & Degradation Extracellular Cytoplasm
Map2k7 Tnf Map3k1 Map4k2 Tank Traf2 Tradd Ripk1 Cradd Casp2 Mapk14 Chuk Ikbkb Ikbkg Nfkb1 Nfkbia Nfkbia Map3k1 Chuk Ikbkb Ikbkg Map2k4 Mapk10 Jun Map2k3 Map2k6 Mapk14 Atf1 Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate NF-κB Tnfrsf1a
Map2k7 Tnf Map3k1 Map4k2 Tank Traf2 Tradd Ripk1 Cradd Casp2 Mapk14 Chuk Ikbkb Ikbkg Nfkb1 Nfkbia Nfkbia Map3k1 Chuk Ikbkb Ikbkg Map2k4 Mapk10 Jun Map2k3 Map2k6 Mapk14 Atf1 Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi NF-κB Tnfrsf1a IKB Ubiquitination & Degradation Extracellular Cytoplasm
Map2k7 Tnf Map3k1 Map4k2 Tank Traf2 Tradd Ripk1 Cradd Casp2 Mapk14 Chuk Ikbkb Ikbkg Nfkb1 Nfkbia Nfkbia Map3k1 Chuk Ikbkb Ikbkg Map2k4 Mapk10 Jun Map2k3 Map2k6 Mapk14 Atf1 Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi Pi NF-κB Tnfrsf1a