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Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Guanine nucleotide- binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide- binding protein G(I)/G(S)/G(T) subunit beta-1 BCL2 associated agonist of cell death Adenosine receptor A2b NF-kappa-B inhibitor zeta NF-kappa-B inhibitor zeta NF-kappa-B inhibitor zeta NF-kappa-B inhibitor zeta Adenosine receptor A2b Adenosine receptor A2b Guanine nucleotide- binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide- binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Guanine nucleotide- binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide- binding protein G(I)/G(S)/G(T) subunit beta-1 Adenylate cyclase type 7 Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Adenylate cyclase type 7 cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit beta Rap guanine nucleotide exchange factor 2 Ras-related protein Rap-1A Ras-related protein Rap-1A Rap guanine nucleotide exchange factor 2 Dual specificity mitogen- activated protein kinase kinase 6 Dual specificity mitogen- activated protein kinase kinase 6 Ras-related protein Rap-1A RAF proto-oncogene serine/threonine- protein kinase Dual specificity mitogen- activated protein kinase kinase 6 Dual specificity mitogen- activated protein kinase kinase 6 Mitogen- activated protein kinase 1 Mitogen- activated protein kinase 1 ETS translocation variant 1 ETS translocation variant 1 Rap guanine nucleotide exchange factor 2 Rap guanine nucleotide exchange factor 2 Ras-related protein Rap-1b Ras-related protein Rap-1b Phosphatidylinositol 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Ras-related protein Rap-1b Phosphatidylinositol 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Cyclic AMP-responsive element-binding protein 1 Cyclic AMP-responsive element-binding protein 1 Rho guanine nucleotide exchange factor 9 Rho guanine nucleotide exchange factor 9 Cell division control protein 42 homolog Cell division control protein 42 homolog Serine/threonine- protein kinase PAK 1 Serine/threonine- protein kinase PAK 1 Cell division control protein 42 homolog Aurora kinase A Aurora kinase A Dual specificity mitogen- activated protein kinase kinase 6 Dual specificity mitogen- activated protein kinase kinase 6 Mitogen- activated protein kinase 13 Mitogen- activated protein kinase 13 Transcription factor AP-1 Transcription factor AP-1 Serine/threonine- protein kinase PAK 1 Cell division control protein 42 homolog Serine/threonine- protein kinase PAK 1 Dual specificity mitogen- activated protein kinase kinase 6 Dual specificity mitogen- activated protein kinase kinase 6 Mitogen- activated protein kinase 13 Mitogen- activated protein kinase 13 Activating transcription factor 2 Activating transcription factor 2 cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit beta RAC-alpha serine/threonine- protein kinase RAC-alpha serine/threonine- protein kinase RAC-alpha serine/threonine- protein kinase Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B inhibitor zeta NF-kappa-B inhibitor zeta NF-kappa-B inhibitor zeta NF-kappa-B inhibitor zeta NF-kappa-B inhibitor zeta Par-6 family cell polarity regulator alpha Protein kinase C beta type Cell division control protein 42 homolog Par-6 family cell polarity regulator alpha Protein kinase C beta type Ribosomal protein S6 kinase beta-1 Ribosomal protein S6 kinase beta-1 BCL2 associated agonist of cell death cAMP Adenosine Adenosine GTP GDP Adenosine triphosphate PPi cAMP GTP GDP Pi Pi Pi Pi GTP GDP PIP2(16:0/16:0) PIP3(16:0/16:0) PIP3(16:0/16:0) Pi GTP GDP Pi Pi Pi Pi Pi Pi Pi PIP3(16:0/16:0) PIP3(16:0/16:0) PIP3(16:0/16:0) Pi Pi Pi Pi Pi GDP GTP GDP GTP GDP Guanosine triphosphate Magnesium Guanosine triphosphate Magnesium Magnesium Magnesium Zinc Magnesium Magnesium cAMP Guanosine diphosphate Guanosine triphosphate Guanosine triphosphate Phosphate Guanosine diphosphate Guanosine triphosphate Magnesium Magnesium Guanosine triphosphate Magnesium Magnesium Magnesium Magnesium Magnesium Magnesium Magnesium Guanosine triphosphate Magnesium Magnesium Magnesium Magnesium Magnesium Guanosine triphosphate Regulation of glutamate and Dopamine release in the brain Coronary artery vasodilation in the heart Apoptosis cAMP Transcription Transcription Transcription Transcription Transcription Nucleus Intracellular Space Extracellular Space Activation Activation Activation Activation Regulatory Subunit Regulatory Subunit Inhibition
GNAS GNG12 GNB1 BAD ADORA2B NFKBIZ NFKBIZ NFKBIZ NFKBIZ ADORA2B ADORA2B GNG12 GNB1 GNAS GNAS GNG12 GNB1 ADCY7 GNAS ADCY7 PRKACB PRKACB RAPGEF2 RAP1A RAP1A RAPGEF2 MAP2K6 MAP2K6 RAP1A RAF1 MAP2K6 MAP2K6 MAPK1 MAPK1 ETV1 ETV1 RAPGEF2 RAPGEF2 RAP1B RAP1B PIK3CA RAP1B PIK3CA CREB1 CREB1 ARHGEF9 ARHGEF9 CDC42 CDC42 PAK1 PAK1 CDC42 AURKA AURKA MAP2K6 MAP2K6 MAPK13 MAPK13 JUN JUN PAK1 CDC42 PAK1 MAP2K6 MAP2K6 MAPK13 MAPK13 ATF2 ATF2 PRKACB PRKACB AKT1 AKT1 AKT1 CHUK IKBKB CHUK IKBKB NFKBIZ NFKBIZ NFKBIZ NFKBIZ NFKBIZ PARD6A PRKCB CDC42 PARD6A PRKCB RPS6KB1 RPS6KB1 BAD cAMP Adenosine Adenosine Guanosine triphosphate Guanosine diphosphate Adenosine triphosphate Pyrophosphate cAMP Guanosine triphosphate Guanosine diphosphate Phosphate Phosphate Phosphate Phosphate Guanosine triphosphate Guanosine diphosphate PIP2(16:0/16:0) PIP3(16:0/16:0) PIP3(16:0/16:0) Phosphate Guanosine triphosphate Guanosine diphosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate PIP3(16:0/16:0) PIP3(16:0/16:0) PIP3(16:0/16:0) Phosphate Phosphate Phosphate Phosphate Phosphate Guanosine diphosphate Guanosine triphosphate Guanosine diphosphate Guanosine triphosphate Guanosine diphosphate Regulation of glutamate and Dopamine release in the brain Coronary artery vasodilation in the heart Apoptosis
GNAS GNG12 GNB1 BAD ADORA2B NFKBIZ NFKBIZ NFKBIZ NFKBIZ ADORA2B ADORA2B GNG12 GNB1 GNAS GNAS GNG12 GNB1 ADCY7 GNAS ADCY7 PRKACB PRKACB RAPGEF2 RAP1A RAP1A RAPGEF2 MAP2K6 MAP2K6 RAP1A RAF1 MAP2K6 MAP2K6 MAPK1 MAPK1 ETV1 ETV1 RAPGEF2 RAPGEF2 RAP1B RAP1B PIK3CA RAP1B PIK3CA CREB1 CREB1 ARHGEF9 ARHGEF9 CDC42 CDC42 PAK1 PAK1 CDC42 AURKA AURKA MAP2K6 MAP2K6 MAPK13 MAPK13 JUN JUN PAK1 CDC42 PAK1 MAP2K6 MAP2K6 MAPK13 MAPK13 ATF2 ATF2 PRKACB PRKACB AKT1 AKT1 AKT1 CHUK IKBKB CHUK IKBKB NFKBIZ NFKBIZ NFKBIZ NFKBIZ NFKBIZ PARD6A PRKCB CDC42 PARD6A PRKCB RPS6KB1 RPS6KB1 BAD cAMP Adenosi Adenosi GTP GDP ATP PPi cAMP GTP GDP Pi Pi Pi Pi GTP GDP PIP216 PIP316 PIP316 Pi GTP GDP Pi Pi Pi Pi Pi Pi Pi PIP316 PIP316 PIP316 Pi Pi Pi Pi Pi GDP GTP GDP GTP GDP GTP Mg2+ GTP Mg2+ Mg2+ Mg2+ Zinc Mg2+ Mg2+ cAMP GDP GTP GTP Pi GDP GTP Mg2+ Mg2+ GTP Mg2+ Mg2+ Mg2+ Mg2+ Mg2+ Mg2+ Mg2+ GTP Mg2+ Mg2+ Mg2+ Mg2+ Mg2+ GTP R o g a C a v i Apopt cAMP Transcription Transcription Transcription Transcription Transcription Nucleus Intracellular Space Extracellular Space Activation Activation Activation Activation Regulatory Subunit Regulatory Subunit Inhibition
GNAS GNG12 GNB1 BAD ADORA2B NFKBIZ NFKBIZ NFKBIZ NFKBIZ ADORA2B ADORA2B GNG12 GNB1 GNAS GNAS GNG12 GNB1 ADCY7 GNAS ADCY7 PRKACB PRKACB RAPGEF2 RAP1A RAP1A RAPGEF2 MAP2K6 MAP2K6 RAP1A RAF1 MAP2K6 MAP2K6 MAPK1 MAPK1 ETV1 ETV1 RAPGEF2 RAPGEF2 RAP1B RAP1B PIK3CA RAP1B PIK3CA CREB1 CREB1 ARHGEF9 ARHGEF9 CDC42 CDC42 PAK1 PAK1 CDC42 AURKA AURKA MAP2K6 MAP2K6 MAPK13 MAPK13 JUN JUN PAK1 CDC42 PAK1 MAP2K6 MAP2K6 MAPK13 MAPK13 ATF2 ATF2 PRKACB PRKACB AKT1 AKT1 AKT1 CHUK IKBKB CHUK IKBKB NFKBIZ NFKBIZ NFKBIZ NFKBIZ NFKBIZ PARD6A PRKCB CDC42 PARD6A PRKCB RPS6KB1 RPS6KB1 BAD cAMP Adenosi Adenosi GTP GDP ATP Ppi cAMP GTP GDP Pi Pi Pi Pi GTP GDP PIP216 PIP316 PIP316 Pi GTP GDP Pi Pi Pi Pi Pi Pi Pi PIP316 PIP316 PIP316 Pi Pi Pi Pi Pi GDP GTP GDP GTP GDP R o g a C a v i Apopt