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Alcohol dehydrogenase [NADP(+)] Alcohol dehydrogenase [NADP(+)] Cytochrome P450 2C54 Cytochrome P450 2D9 Alcohol dehydrogenase [NADP(+)] Short-chain dehydrogenase/reductase family 16C member 6 Alcohol dehydrogenase [NADP(+)] Steroid 21-hydroxylase 1,25- dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Steroid 21-hydroxylase Cytochrome P450 2D9 3-beta-HSD 1 Steroid 21-hydroxylase 3-beta-HSD 1 Cytochrome P450 2C54 Steroid 21-hydroxylase Cytochrome P450 2D9 Cytochrome P450 2D9 1,25- dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Steroid 21-hydroxylase 3-beta-HSD 1 3-beta-HSD 1 1,25- dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Steroid 21-hydroxylase Cytochrome P450 2C39 Cytochrome P450 2C39 Cytochrome P450 2C39 Cytochrome P450 2C39 Cytochrome P450 2C39 Cytochrome P450 2C39 1,25- dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Alcohol dehydrogenase [NADP(+)] Alcohol dehydrogenase [NADP(+)] Alcohol dehydrogenase [NADP(+)] Alcohol dehydrogenase [NADP(+)] Cytochrome P450 2D9 Alcohol dehydrogenase [NADP(+)] Alcohol dehydrogenase [NADP(+)] Corticosteroid 11-beta- dehydrogenase isozyme 2 Corticosteroid 11-beta- dehydrogenase isozyme 2 Short-chain dehydrogenase/reductase family 42E member 1 Cholesterol Accumulation Progesterone Accumulation Progesterone 11b,21-Dihydroxy-3,20-oxo- 5b-pregnan-18-al NADPH 3a,11b,21-Trihydroxy-20-oxo- 5b-pregnan-18-al NADP NADP Aldosterone NADPH 18-Hydroxycorticosterone O2 H2O Corticosterone O2 H2O 11b,21-Dihydroxy-5b- pregnane-3,20-dione Tetrahydrocorticosterone NADP NADPH Accumulation 11-Dehydrocorticosterone 21-Hydroxy-5b-pregnane- 3,11,20-trione NADP 3a,21-Dihydroxy-5b-pregnane- 11,20-dione NADPH NADP NADPH 11b-Hydroxyprogesterone 21-Deoxycortisol Cortisol Accumulation Deoxycorticosterone 21-Hydroxypregnenolone NAD NADH Accumulation Pregnenolone NAD NADH 17-Hydroxyprogesterone Cortexolone 17a-Hydroxypregnenolone NAD NADH NADH 17α,21-Dihydroxypregnenolone NAD 20a,22b-Dihydroxycholesterol 4- Methylpentanal 17a,20a-Dihydroxycholesterol 22b-Hydroxycholesterol 20α-Hydroxycholesterol 17a,21-Dihydroxy-5b- pregnane-3,11,20-trione NADP Cortisone NADPH Tetrahydrocortisone NADP NADPH Dihydrocortisol NADP NADPH Tetrahydrocortisol NADP NADPH O2 11b,17a,21-Trihydroxypreg- nenolone H2O NADPH 5a-Pregnane-3,20-dione NADP 3a-Hydroxy-5b-pregnane-20-one NADP NADPH NADP NADPH Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Steroid Biosynthesis Adrenal Gland Smooth Endoplasmic Reticulum Smooth Endoplasmic Reticulum ER Membrane ER Membrane ER Membrane Mitochondrion Mitochondrion Mitochondrion Mitochondrion Intracellular Space Extracellular Space Inner mitochondria membrane Outer mitochondria membrane
Endoplasmic Reticulum Mitochondria Endoplasmic Reticulum Akr1a1 Akr1a1 Cyp2c54 Cyp2d9 Akr1a1 Sdr16c6 Akr1a1 Cyp21 Cyp24a1 Cyp21 Cyp2d9 Sdr42e1 Cyp21 Sdr42e1 Cyp2c54 Cyp21 Cyp2d9 Cyp2d9 Cyp24a1 Cyp21 Sdr42e1 Sdr42e1 Cyp24a1 Cyp21 Cyp2c39 Cyp2c39 Cyp2c39 Cyp2c39 Cyp2c39 Cyp2c39 Cyp24a1 Akr1a1 Akr1a1 Akr1a1 Akr1a1 Cyp2d9 Akr1a1 Akr1a1 Hsd11b2 Hsd11b2 Sdr42e1 Cholesterol Accumulation Progesterone Accumulation Progesterone 11b,21- Dihydroxy- 3,20-oxo-5b- pregnan-18-al NADPH 3a,11b,21- Trihydroxy- 20-oxo-5b- pregnan-18-al NADP NADP Aldosterone NADPH 18- Hydroxycorticosterone Oxygen Water Corticosterone Oxygen Water 11b,21- Dihydroxy-5b- pregnane- 3,20-dione Tetrahydrocorticosterone NADP NADPH Accumulation 11- Dehydrocorticosterone 21-Hydroxy- 5b-pregnane- 3,11,20- trione NADP 3a,21- Dihydroxy-5b- pregnane- 11,20-dione NADPH NADP NADPH 11b- Hydroxyprogesterone 21- Deoxycortisol Cortisol Accumulation Deoxycorticosterone 21- Hydroxypregnenolone NAD NADH Accumulation Pregnenolone NAD NADH 17- Hydroxyprogesterone Cortexolone 17a- Hydroxypregnenolone NAD NADH NADH 17α,21- Dihydroxypregnenolone NAD 20a,22b- Dihydroxycholesterol 4- Methylpentanal 17a,20a- Dihydroxycholesterol 22b- Hydroxycholesterol 20α- Hydroxycholesterol 17a,21- Dihydroxy-5b- pregnane- 3,11,20- trione NADP Cortisone NADPH Tetrahydrocortisone NADP NADPH Dihydrocortisol NADP NADPH Tetrahydrocortisol NADP NADPH Oxygen 11b,17a,21- Trihydroxypreg- nenolone Water NADPH 5a-Pregnane- 3,20-dione NADP 3a-Hydroxy- 5b-pregnane- 20-one NADP NADPH NADP NADPH Steroid Biosynthesis
Akr1a1 Akr1a1 Cyp2c54 Cyp2d9 Akr1a1 Sdr16c6 Akr1a1 Cyp21 Cyp24a1 Cyp21 Cyp2d9 Sdr42e1 Cyp21 Sdr42e1 Cyp2c54 Cyp21 Cyp2d9 Cyp2d9 Cyp24a1 Cyp21 Sdr42e1 Sdr42e1 Cyp24a1 Cyp21 Cyp2c39 Cyp2c39 Cyp2c39 Cyp2c39 Cyp2c39 Cyp2c39 Cyp24a1 Akr1a1 Akr1a1 Akr1a1 Akr1a1 Cyp2d9 Akr1a1 Akr1a1 Hsd11b2 Hsd11b2 Sdr42e1 Lanol Accumulation Prgstrn Accumulation Prgstrn NA NADPH T20OPal NADP NADP Aldostr NADPH 18-HCC O2 H2O Cortcos O2 H2O 11B21D5 Tetrahy NADP NADPH Accumulation 11dhccn 21-Hydr NADP 321D5B NADPH NADP NADPH 11Hprgt 21HOCrt HC Accumulation Doct 21-Hpgn NAD NADH Accumulation Pregnen NAD NADH 17-OHP Cortexo 17a-HP NAD NADH NADH 17ADhp NAD OH2chol 4-MPnal 17aDhch 22b-HC 20a-HC DHPRGT NADP Corlin NADPH TetraHC NADP NADPH DHCort NADP NADPH tetHCol NADP NADPH O2 Trihpnn H2O NADPH P3D NADP 3aH5bPO NADP NADPH NADP NADPH Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme PW000050 Adrenal Gland Smooth Endoplasmic Reticulum Smooth Endoplasmic Reticulum ER Membrane ER Membrane ER Membrane Mitochondrion Mitochondrion Mitochondrion Mitochondrion Intracellular Space Extracellular Space Inner mitochondria membrane Outer mitochondria membrane
Endoplasmic Reticulum Mitochondria Endoplasmic Reticulum Akr1a1 Akr1a1 Cyp2c54 Cyp2d9 Akr1a1 Sdr16c6 Akr1a1 Cyp21 Cyp24a1 Cyp21 Cyp2d9 Sdr42e1 Cyp21 Sdr42e1 Cyp2c54 Cyp21 Cyp2d9 Cyp2d9 Cyp24a1 Cyp21 Sdr42e1 Sdr42e1 Cyp24a1 Cyp21 Cyp2c39 Cyp2c39 Cyp2c39 Cyp2c39 Cyp2c39 Cyp2c39 Cyp24a1 Akr1a1 Akr1a1 Akr1a1 Akr1a1 Cyp2d9 Akr1a1 Akr1a1 Hsd11b2 Hsd11b2 Sdr42e1 Lanol Accumulation Prgstrn Accumulation Prgstrn NA NADPH T20OPal NADP NADP Aldostr NADPH 18-HCC O2 H2O Cortcos O2 H2O 11B21D5 Tetrahy NADP NADPH Accumulation 11dhccn 21-Hydr NADP 321D5B NADPH NADP NADPH 11Hprgt 21HOCrt HC Accumulation Doct 21-Hpgn NAD NADH Accumulation Pregnen NAD NADH 17-OHP Cortexo 17a-HP NAD NADH NADH 17ADhp NAD OH2chol 4-MPnal 17aDhch 22b-HC 20a-HC DHPRGT NADP Corlin NADPH TetraHC NADP NADPH DHCort NADP NADPH tetHCol NADP NADPH O2 Trihpnn H2O NADPH P3D NADP 3aH5bPO NADP NADPH NADP NADPH PW000050