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Excitatory amino acid transporter 1 Excitatory amino acid transporter 1 Mitochondrial ornithine transporter 1 Mitochondrial ornithine transporter 1 Mitochondrial glutamate carrier 2 Alanine aminotransferase 1 Glutaminase liver isoform, mitochondrial Glutamate dehydrogenase 1, mitochondrial Carbamoyl- phosphate synthase [ammonia], mitochondrial Aspartate aminotransferase, mitochondrial Ornithine carbamoyltransferase, mitochondrial Arginase-1 Argininosuccinate lyase Argininosuccinate synthase L-Glutamine L-Alanine Oxoglutaric acid L-Glutamic acid Oxalacetic acid NH3 L-Aspartic acid Fumaric acid Accumulation L-Arginine Ornithine L-Glutamine L-Alanine Ornithine Citrulline Citrulline Ornithine Ornithine Citrulline Citrulline L-Aspartic acid L-Glutamic acid L-Glutamic acid Pyruvic acid H2O H2O NAD Oxoglutaric acid NADH ATP CO2 H2O ADP Pi Carbamoyl phosphate Pi H2O Urea Accumulation Argininosuccinic acid ATP AMP PPi Calcium Pyridoxal 5'-phosphate Pyridoxal 5'-phosphate Manganese Ammonia Recycling Pyrimidine Metabolism Glutamate Metabolism Alanine Metabolism Glucose-Alanine Cycle Selenoamino Acid Metabolism Malate- Aspartate Shuttle Glutamate Metabolism Alanine Metabolism Glucose-Alanine Cycle Gluconeogenesis Histidine Metabolism Porphyrin Metabolism Glucose-Alanine Cycle Porphyrin Metabolism Alanine Metabolism Ammonia Recycling Glutamate Metabolism Glucose-Alanine Cycle Ammonia Recycling Purine Metabolism Glucose-Alanine Cycle Aspartate Metabolism Citric Acid Cycle Arginine and Proline Metabolism D-Arginine and D-Ornithine Metabolism D-Arginine and D-Ornithine Metabolism Cytosol Mitochondria Mitochondrial Matrix Urea Cycle Extracellular Space Intracellular Space
Mitochondria Slc1a3 Slc1a3 Slc25a15 Slc25a15 Slc25a18 Gpt Gls2 Glud1 Cps1 Got2 Otc Arg1 Asl Ass1 L-Glutamine L-Alanine Oxoglutaric acid L-Glutamic acid Oxalacetic acid Ammonia L-Aspartic acid Fumaric acid Accumulation L-Arginine Ornithine L-Glutamine L-Alanine Ornithine Citrulline Citrulline Ornithine Ornithine Citrulline Citrulline L-Aspartic acid L-Glutamic acid L-Glutamic acid Pyruvic acid Water Water NAD Oxoglutaric acid NADH Adenosine triphosphate Carbon dioxide Water Adenosine diphosphate Phosphoric acid Carbamoyl phosphate Phosphate Water Urea Accumulation Argininosuccinic acid Adenosine triphosphate Adenosine monophosphate Pyrophosphate Ammonia Recycling Pyrimidine Metabolism Glutamate Metabolism Alanine Metabolism Glucose-Alanine Cycle Selenoamino Acid Metabolism Malate- Aspartate Shuttle Glutamate Metabolism Alanine Metabolism Glucose-Alanine Cycle Gluconeogenesis Histidine Metabolism Porphyrin Metabolism Glucose-Alanine Cycle Porphyrin Metabolism Alanine Metabolism Ammonia Recycling Glutamate Metabolism Glucose-Alanine Cycle Ammonia Recycling Purine Metabolism Glucose-Alanine Cycle Aspartate Metabolism Citric Acid Cycle Arginine and Proline Metabolism D-Arginine and D-Ornithine Metabolism D-Arginine and D-Ornithine Metabolism
Slc1a3 Slc1a3 Slc25a15 Slc25a15 Slc25a18 Gpt Gls2 Glud1 Cps1 Got2 Otc Arg1 Asl Ass1 Gln Ala AKG Glu Oaa NH3 Asp Fumarat Accumulation Arg Ornithi Gln Ala Ornithi Citruln Citruln Ornithi Ornithi Citruln Citruln Asp Glu Glu Pyr H2O H2O NAD AKG NADH ATP CO2 H2O ADP Pi CarbmP Pi H2O Urea Accumulation ASA ATP AMP PPi Ca2+ Pyr-5'P Pyr-5'P Mn2+ PW000009 PW000160 PW000003 PW000001 PW000046 PW000007 PW000030 PW000003 PW000001 PW000046 PW000152 PW000043 PW000158 PW000046 PW000158 PW000001 PW000009 PW000003 PW000046 PW000009 PW000052 PW000046 PW000002 PW000005 PW000010 PW000019 PW000019 Cytosol Mitochondria Mitochondrial Matrix Urea Cycle Extracellular Space Intracellular Space
Mitochondria Slc1a3 Slc1a3 Slc25a15 Slc25a15 Slc25a18 Gpt Gls2 Glud1 Cps1 Got2 Otc Arg1 Asl Ass1 Gln Ala AKG Glu Oaa NH3 Asp Fumarat Accumulation Arg Ornithi Gln Ala Ornithi Citruln Citruln Ornithi Ornithi Citruln Citruln Asp Glu Glu Pyr H2O H2O NAD AKG NADH ATP CO2 H2O ADP PhosfrA CarbmP Pi H2O Urea Accumulation ASA ATP AMP Ppi PW000009 PW000160 PW000003 PW000001 PW000046 PW000007 PW000030 PW000003 PW000001 PW000046 PW000152 PW000043 PW000158 PW000046 PW000158 PW000001 PW000009 PW000003 PW000046 PW000009 PW000052 PW000046 PW000002 PW000005 PW000010 PW000019 PW000019