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Carbamoyl- phosphate synthase [ammonia], mitochondrial Carbamoyl- phosphate synthase [ammonia], mitochondrial Carbamoyl- phosphate synthase [ammonia], mitochondrial Dihydroorotate dehydrogenase (quinone), mitochondrial Unknown Unknown Soluble calcium- activated nucleotidase 1 Cytidine/uridine monophosphate kinase 2 Nucleoside diphosphate kinase 6 Soluble calcium- activated nucleotidase 1 GTP:AMP phosphotransferase AK3, mitochondrial Inosine triphosphate pyrophosphatase CTP synthase 2 Soluble calcium- activated nucleotidase 1 Nucleoside diphosphate kinase 6 Soluble calcium- activated nucleotidase 1 Cytidine/uridine monophosphate kinase 2 5'-nucleotidase domain- containing protein 2 Guanine deaminase 5'-nucleotidase domain- containing protein 2 Uridine phosphorylase Dihydropyrimidine dehydrogenase [NADP(+)] Dihydropyrimidinase Beta- ureidopropionase Ribonucleoside- diphosphate reductase large subunit Nucleoside diphosphate kinase 6 Cytidine/uridine monophosphate kinase 2 5'-nucleotidase domain- containing protein 2 Uridine- cytidine kinase 2 Cytidine deaminase Thymidine phosphorylase Deoxycytidylate deaminase Thymidine kinase, cytosolic Thymidylate synthase Thymidylate synthase Soluble calcium- activated nucleotidase 1 Nucleoside diphosphate kinase 6 Soluble calcium- activated nucleotidase 1 5'-nucleotidase domain- containing protein 2 Thymidine kinase, cytosolic Thymidine phosphorylase Dihydropyrimidine dehydrogenase [NADP(+)] Dihydropyrimidinase Beta- ureidopropionase Deoxyuridine 5'-triphosphate nucleotidohydrolase Nucleoside diphosphate kinase 6 Thymidylate synthase Ribonucleoside- diphosphate reductase large subunit Uridine- cytidine kinase 2 Beta- ureidopropionase Uridine triphosphate Cytidine triphosphate Uridine 5'-diphosphate CDP dCTP Thymidine 5'-triphosphate β-Alanine L-Glutamine Carbamoyl phosphate Phosphoribosyl pyrophosphate 3- Aminoisobutanoic acid ATP H2O Hydrogen carbonate ADP Pi Ureidosuccinic acid L-Dihydroorotic acid Quinone Accumulation Orotic acid Orotidylic acid Uridine 5'-monophosphate H2O Pi ATP ADP ADP ATP H2O Pi ADP AMP H2O PPi ATP ADP Pi dCTP H2O Pi ADP ATP H2O Cytidine monophosphate Pi ADP ATP H2O Cytidine Pi H2O Uridine NH3 H2O Pi Pi Accumulation Uracil Ribose 1-phosphate NADP Dihydrouracil NADPH H2O Ureidopropionic acid H2O NH3 CO2 H2O dCDP ATP ADP dCMP ATP ADP H2O Deoxycytidine Pi ATP ADP H2O Deoxyuridine NH3 Pi Deoxyribose 1-phosphate H2O dUMP NH3 ATP ADP 5,10-Methylene-THF 5-Thymidylic acid Dihydrofolic acid ATP dTDP ADP H2O Pi ATP ADP H2O Pi H2O Thymidine Pi ATP ADP Pi Thymine Deoxyribose 1-phosphate NADP Dihydrothymine NADPH H2O Ureidoisobutyric acid H2O Ureidoisobutyric acid NH3 CO2 Deoxyuridine triphosphate H2O Pi ADP dUDP ATP ATP ADP Uridine 5'-diphosphate H2O ATP ADP H2O CO2 NH3 Zinc (II) ion Zinc (II) ion Zinc (II) ion Flavin Mononucleotide Calcium Magnesium Calcium Magnesium Calcium Magnesium Calcium Magnesium Zinc (II) ion Magnesium FAD Flavin Mononucleotide Zinc (II) ion Zinc (II) ion Fe2+ Magnesium Magnesium FAD Zinc Calcium Magnesium Calcium Magnesium FAD Flavin Mononucleotide Zinc (II) ion Zinc (II) ion Magnesium Magnesium Fe2+ Zinc (II) ion quinol thioredoxin disulfide thioredoxin Thioredoxin disulfide Thioredoxin DNA reaction RNA reaction Alanine Metabolism Glutamate Metabolism Urea Cycle Pentose Phosphate Pathway Valine, Leucine, and Isoleucine Degradation Intracellular Space Mitochondria Extracellular Space
Cps1 Cps1 Cps1 Dhodh Unknown Unknown Cant1 Cmpk2 Nme6 Cant1 Ak3 Itpa Ctps2 Cant1 Nme6 Cant1 Cmpk2 Nt5dc2 Gda Nt5dc2 Upp2 Dpyd Dpys Upb1 Rrm2 Rrm2 Nme6 Cmpk2 Nt5dc2 Uck2 Cda Tymp Dctd Tk1 Tyms Tyms Cant1 Nme6 Cant1 Nt5dc2 Tk1 Tymp Dpyd Dpys Upb1 Dut Nme6 Tyms Rrm2 Rrm2 Uck2 Upb1 Uridine triphosphate Cytidine triphosphate Uridine 5'-diphosphate CDP dCTP Thymidine 5'-triphosphate β-Alanine L-Glutamine Carbamoyl phosphate Phosphoribosyl pyrophosphate 3- Aminoisobutanoic acid Adenosine triphosphate Water Hydrogen carbonate Adenosine diphosphate Phosphate Ureidosuccinic acid L-Dihydroorotic acid Quinone Accumulation Orotic acid Orotidylic acid Uridine 5'- monophosphate Water Phosphate Adenosine triphosphate Adenosine diphosphate Adenosine diphosphate Adenosine triphosphate Water Phosphoric acid Adenosine diphosphate 3'-AMP Water Pyrophosphate Adenosine triphosphate Adenosine diphosphate Phosphate dCTP Water Phosphate Adenosine diphosphate Adenosine triphosphate Water Cytidine monophosphate Phosphate Adenosine diphosphate Adenosine triphosphate Water Cytidine Phosphoric acid Water Uridine Ammonia Water Phosphate Phosphate Accumulation Uracil Ribose 1-phosphate NADP Dihydrouracil NADPH Water Ureidopropionic acid Water Ammonia Carbon dioxide Water dCDP Adenosine triphosphate Adenosine diphosphate dCMP Adenosine triphosphate Adenosine diphosphate Water Deoxycytidine Phosphate Adenosine triphosphate Adenosine diphosphate Water Deoxyuridine Ammonia Phosphate Deoxyribose 1-phosphate Water dUMP Ammonia Adenosine triphosphate Adenosine diphosphate 5,10- Methylene-THF 5-Thymidylic acid Dihydrofolic acid Adenosine triphosphate dTDP Adenosine diphosphate Water Phosphate Adenosine triphosphate Adenosine diphosphate Water Phosphate Water Thymidine Phosphate Adenosine triphosphate Adenosine diphosphate Phosphate Thymine Deoxyribose 1-phosphate NADP Dihydrothymine NADPH Water Ureidoisobutyric acid Water Ureidoisobutyric acid Ammonia Carbon dioxide Deoxyuridine triphosphate Water Phosphate Adenosine diphosphate dUDP Adenosine triphosphate Adenosine triphosphate Adenosine diphosphate Uridine 5'-diphosphate Water Adenosine triphosphate Adenosine diphosphate Water Carbon dioxide Ammonia quinol thioredoxin disulfide thioredoxin Thioredoxin disulfide Thioredoxin DNA reaction RNA reaction Alanine Metabolism Glutamate Metabolism Urea Cycle Pentose Phosphate Pathway Valine, Leucine, and Isoleucine Degradation
Cps1 Cps1 Cps1 Dhodh Cant1 Cmpk2 Nme6 Cant1 Ak3 Itpa Ctps2 Cant1 Nme6 Cant1 Cmpk2 Nt5dc2 Gda Nt5dc2 Upp2 Dpyd Dpys Upb1 Rrm2 Rrm2 Nme6 Cmpk2 Nt5dc2 Uck2 Cda Tymp Dctd Tk1 Tyms Tyms Cant1 Nme6 Cant1 Nt5dc2 Tk1 Tymp Dpyd Dpys Upb1 Dut Nme6 Tyms Rrm2 Rrm2 Uck2 Upb1 UTP CTP UDP CDP dCTP Tm5TP b-Ala Gln CarbmP PRPP AmnIsoB ATP H2O HCO3 ADP Pi USuccA L-Dhoa Quinone Accumulation Orotate OMP U-5-P H2O Pi ATP ADP ADP ATP H2O Pi ADP AMP H2O PPi ATP ADP Pi dCTP H2O Pi ADP ATP H2O CMP Pi ADP ATP H2O Cytdin Pi H2O Uridine NH3 H2O Pi Pi Accumulation Uracil Rib-1P NADP DUC NADPH H2O Ureidop H2O NH3 CO2 H2O dCDP ATP ADP dCMP ATP ADP H2O DC Pi ATP ADP H2O Du NH3 Pi D1P H2O dUMP NH3 ATP ADP 5XM-THF 5TMA FAH2 ATP dTDP ADP H2O Pi ATP ADP H2O Pi H2O T Pi ATP ADP Pi Thymine D1P NADP DHThy NADPH H2O UrisoBa H2O UrisoBa NH3 CO2 dUTP H2O Pi ADP dUDP ATP ATP ADP UDP H2O ATP ADP H2O CO2 NH3 Zinc Zinc Zinc FlvnMnt Ca2+ Mg2+ Ca2+ Mg2+ Ca2+ Mg2+ Ca2+ Mg2+ Zinc Mg2+ FAD FlvnMnt Zinc Zinc Fe2+ Mg2+ Mg2+ FAD Zinc Ca2+ Mg2+ Ca2+ Mg2+ FAD FlvnMnt Zinc Zinc Mg2+ Mg2+ Fe2+ Zinc quinol TD Thiored TD Thiored DNA rea RNA rea PW000001 PW000003 PW000162 PW000055 PW000051 Intracellular Space Mitochondria Extracellular Space