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Pyruvate
carboxylase,
mitochondrial
L-lactate
dehydrogenase A
chain
Pyruvate kinase
PKLR
Phosphoenolpyruvate
carboxykinase,
cytosolic [GTP]
Malate
dehydrogenase,
cytoplasmic
D-2-
hydroxyglutarate
dehydrogenase,
mitochondrial
Hydroxyacylglutathione
hydrolase,
mitochondrial
Lactoylglutathione
lyase
D-3-
phosphoglycerate
dehydrogenase
Aldose
reductase
Aldose
reductase
NADP-dependent
malic enzyme
Dihydrolipoyl
dehydrogenase
E3
Dihydrolipoyl
transacetylase
E2
Acetyl-CoA
carboxylase 1
Acetyl-CoA
acetyltransferase,
mitochondrial
Acyl-coenzyme A
thioesterase 12
Acylphosphatase-
2
Aldehyde
dehydrogenase,
mitochondrial
Acyl-CoA
synthetase
short-chain
family member 2
Acyl-CoA
synthetase
short-chain
family member 2
Pyruvate
dehydrogenase
E1
Accumulation
Pyruvic acid
Oxalacetic acid
Phosphoenolpyruvic acid
Pyruvaldehyde
Acetyl-CoA
Acetoacetyl-CoA
ATP
HCO3 -
ADP
Pi
L-Lactic acid
NAD
NADH
H+
ATP
ADP
GTP
GDP
CO2
L-Malic acid
NAD
NADH
H+
NAD
CO2
NADH
H+
D-Lactic acid
H+
S-Lactoylglutathione
H2 O
Glutathione
Glutathione
D-Lactaldehyde
NAD
NADH
H+
Lactaldehyde
NAD
H+
NADH
Propylene
glycol
NADP
H+
NADPH
NADP
CO2
NADPH
Dihydrolipoamide
NAD
Lipoamide
NADH
H+
S-Acetyldihydrolipoamide-E
Coenzyme A
ATP
HCO3 -
Pi
ADP
Malonyl-CoA
Coenzyme A
CoA
Acetic acid
H2 O
Acetylphosphate
H2 O
Pi
Acetaldehyde
NAD
H2 O
NADH
H+
ATP
PPi
Acetyl adenylate
AMP
PPi
ATP
CO2
Biotin
Manganese
Magnesium
Potassium
Manganese
Zinc (II) ion
Zinc (II) ion
Manganese
FAD
Biotin
Manganese
Thiamine
pyrophosphate
Ferricytochrome
c
Ferrocytochrome
c
Nicotinate and
Nicotinamide
Metabolism
Valine,
Leucine, and
Isoleucine
Degradation
Citric Acid
Cycle
Glycolysis
Glycine and
Serine
Metabolism
Propanoate
Metabolism
Ketone Body
Metabolism
Intracellular Space
Mitochondria
Mitochondrial matrix
Pc
Ldha
Pklr
Pck1
Mdh1
D2hgdh
Hagh
Glo1
Phgdh
Akr1b1
Akr1b1
Me1
Dld
Dlat
Acaca
Acat1
Acot12
Acyp2
Aldh2
Acss2
Acss2
Pdha1
Pdhb
Accumulation
Pyruvic acid
Oxalacetic acid
Phosphoenolpyruvic
acid
Pyruvaldehyde
Acetyl-CoA
Acetoacetyl-CoA
Adenosine
triphosphate
Hydrogen
carbonate
Adenosine
diphosphate
Phosphate
L-Lactic acid
NAD
NADH
Hydrogen Ion
Adenosine
triphosphate
Adenosine
diphosphate
Guanosine
triphosphate
Guanosine
diphosphate
Carbon dioxide
L-Malic acid
NAD
NADH
Hydrogen Ion
NAD
Carbon dioxide
NADH
Hydrogen Ion
D-Lactic acid
Hydrogen Ion
S-
Lactoylglutathione
Water
Glutathione
Glutathione
D-Lactaldehyde
NAD
NADH
Hydrogen Ion
Lactaldehyde
NAD
Hydrogen
NADH
Propylene
glycol
NADP
Hydrogen Ion
NADPH
NADP
Carbon dioxide
NADPH
Dihydrolipoamide
NAD
Lipoamide
NADH
Hydrogen Ion
S-
Acetyldihydrolipoamide-
E
Coenzyme A
Adenosine
triphosphate
Hydrogen
carbonate
Phosphoric acid
Adenosine
diphosphate
Malonyl-CoA
Coenzyme A
Coenzyme A
Acetic acid
Water
Acetylphosphate
Water
Phosphoric acid
Acetaldehyde
NAD
Water
NADH
Hydrogen Ion
Adenosine
triphosphate
Pyrophosphate
Acetyl
adenylate
Adenosine
monophosphate
Pyrophosphate
Adenosine
triphosphate
Carbon dioxide
Ferricytochrome
c
Ferrocytochrome
c
Nicotinate and
Nicotinamide
Metabolism
Valine,
Leucine, and
Isoleucine
Degradation
Citric Acid
Cycle
Glycolysis
Glycine and
Serine
Metabolism
Propanoate
Metabolism
Ketone Body
Metabolism
Pc
Ldha
Pklr
Pck1
Mdh1
D2hgdh
Hagh
Glo1
Phgdh
Akr1b1
Akr1b1
Me1
Dld
Dlat
Acaca
Acat1
Acot12
Acyp2
Aldh2
Acss2
Acss2
Pdha1
Pdhb
Accumulation
Pyr
Oaa
Pep
Pyruval
Ac-CoA
ActaCoA
ATP
HCO3 -
ADP
Pi
Lactate
NAD
NADH
H+
ATP
ADP
GTP
GDP
CO2
Malate
NAD
NADH
H+
NAD
CO2
NADH
H+
D-Lac
H+
S-LacGu
H2 O
GSH
GSH
DL
NAD
NADH
H+
LacAlhd
NAD
H+
NADH
PGlycol
NADP
H+
NADPH
NADP
CO2
NADPH
DHLipoa
NAD
Lipoamd
NADH
H+
SAE
CoA
ATP
HCO3 -
Pi
ADP
MalyCoA
CoA
CoA
Acoh
H2 O
AcetylP
H2 O
Pi
Ethanal
NAD
H2 O
NADH
H+
ATP
PPi
AAD
AMP
PPi
ATP
CO2
Biotin
Mn2+
Mg2+
K+
Mn2+
Zinc
Zinc
Mn2+
FAD
Biotin
Mn2+
ThiamPP
FC
FC
PW000151
PW000051
PW000005
PW000146
PW000157
PW000149
PW000028
Intracellular Space
Mitochondria
Mitochondrial matrix
Pc
Ldha
Pklr
Pck1
Mdh1
D2hgdh
Hagh
Glo1
Phgdh
Akr1b1
Akr1b1
Me1
Dld
Dlat
Acaca
Acat1
Acot12
Acyp2
Aldh2
Acss2
Acss2
Pdha1
Pdhb
Accumulation
Pyr
Oaa
Pep
Pyruval
Ac-CoA
ActaCoA
ATP
HCO3
ADP
Pi
Lactate
NAD
NADH
H+
ATP
ADP
GTP
GDP
CO2
Malate
NAD
NADH
H+
NAD
CO2
NADH
H+
D-Lac
H+
S-LacGu
H2O
GSH
GSH
DL
NAD
NADH
H+
LacAlhd
NAD
H2
NADH
PGlycol
NADP
H+
NADPH
NADP
CO2
NADPH
DHLipoa
NAD
Lipoamd
NADH
H+
SAE
CoA
ATP
HCO3
PhosfrA
ADP
MalyCoA
CoA
CoA
Acoh
H2O
AcetylP
H2O
PhosfrA
Ethanal
NAD
H2O
NADH
H+
ATP
Ppi
AAD
AMP
Ppi
ATP
CO2
FC
FC
PW000151
PW000051
PW000005
PW000146
PW000157
PW000149
PW000028