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3-alpha- hydroxysteroid dehydrogenase 3-oxo-5-beta- steroid 4-dehydrogenase Cytochrome P450 11B3, mitochondrial Cytochrome P450 11B3, mitochondrial 3-alpha- hydroxysteroid dehydrogenase Corticosteroid 11-beta- dehydrogenase isozyme 1 3-alpha- hydroxysteroid dehydrogenase Steroid 21-hydroxylase Steroid 17-alpha- hydroxylase/17,20 lyase Steroid 21-hydroxylase Cytochrome P450 11B3, mitochondrial 3-beta-HSD 1 Steroid 21-hydroxylase 3-beta-HSD 1 Cytochrome P450 11B3, mitochondrial Steroid 21-hydroxylase Cytochrome P450 11B3, mitochondrial Cytochrome P450 11B3, mitochondrial Steroid 17-alpha- hydroxylase/17,20 lyase Steroid 21-hydroxylase 3-beta-HSD 1 3-beta-HSD 1 Steroid 17-alpha- hydroxylase/17,20 lyase Steroid 21-hydroxylase Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Steroid 17-alpha- hydroxylase/17,20 lyase 3-oxo-5-beta- steroid 4-dehydrogenase 3-alpha- hydroxysteroid dehydrogenase 3-oxo-5-beta- steroid 4-dehydrogenase 3-alpha- hydroxysteroid dehydrogenase Cytochrome P450 11B3, mitochondrial 3-oxo-5-beta- steroid 4-dehydrogenase 3-alpha- hydroxysteroid dehydrogenase Corticosteroid 11-beta- dehydrogenase isozyme 2 Corticosteroid 11-beta- dehydrogenase isozyme 2 3 beta- hydroxysteroid dehydrogenase type 5 Cholesterol Accumulation Progesterone Accumulation Progesterone 11b,21-Dihydroxy-3,20-oxo- 5b-pregnan-18-al NADPH 3a,11b,21-Trihydroxy-20-oxo- 5b-pregnan-18-al NADP NADP Aldosterone NADPH 18-Hydroxycorticosterone O2 H2O Corticosterone O2 H2O 11b,21-Dihydroxy-5b- pregnane-3,20-dione Tetrahydrocorticosterone NADP NADPH Accumulation 11-Dehydrocorticosterone 21-Hydroxy-5b-pregnane- 3,11,20-trione NADP 3a,21-Dihydroxy-5b-pregnane- 11,20-dione NADPH NADP NADPH 11b-Hydroxyprogesterone 21-Deoxycortisol Cortisol Accumulation Deoxycorticosterone 21-Hydroxypregnenolone NAD NADH Accumulation Pregnenolone NAD NADH 17-Hydroxyprogesterone Cortexolone 17a-Hydroxypregnenolone NAD NADH NADH 17α,21-Dihydroxypregnenolone NAD 20a,22b-Dihydroxycholesterol 4- Methylpentanal 17a,20a-Dihydroxycholesterol 22b-Hydroxycholesterol 20α-Hydroxycholesterol 17a,21-Dihydroxy-5b- pregnane-3,11,20-trione NADP Cortisone NADPH Tetrahydrocortisone NADP NADPH Dihydrocortisol NADP NADPH Tetrahydrocortisol NADP NADPH O2 11b,17a,21-Trihydroxypreg- nenolone H2O NADPH 5a-Pregnane-3,20-dione NADP 3a-Hydroxy-5b-pregnane-20-one NADP NADPH NADP NADPH Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Steroid Biosynthesis Adrenal Gland Smooth Endoplasmic Reticulum Smooth Endoplasmic Reticulum ER Membrane ER Membrane ER Membrane Mitochondrion Mitochondrion Mitochondrion Mitochondrion Intracellular Space Extracellular Space Inner mitochondria membrane Outer mitochondria membrane
Endoplasmic Reticulum Mitochondria Endoplasmic Reticulum Akr1c9 Akr1d1 Cyp11b3 Cyp11b3 Akr1c9 Hsd11b1 Akr1c9 Cyp21 Cyp17a1 Cyp21 Cyp11b3 Hsd3b5 Cyp21 Hsd3b5 Cyp11b3 Cyp21 Cyp11b3 Cyp11b3 Cyp17a1 Cyp21 Hsd3b5 Hsd3b5 Cyp17a1 Cyp21 Cyp11a1 Cyp11a1 Cyp11a1 Cyp11a1 Cyp11a1 Cyp11a1 Cyp17a1 Akr1d1 Akr1c9 Akr1d1 Akr1c9 Cyp11b3 Akr1d1 Akr1c9 Hsd11b2 Hsd11b2 Hsd3b5 Cholesterol Accumulation Progesterone Accumulation Progesterone 11b,21- Dihydroxy- 3,20-oxo-5b- pregnan-18-al NADPH 3a,11b,21- Trihydroxy- 20-oxo-5b- pregnan-18-al NADP NADP Aldosterone NADPH 18- Hydroxycorticosterone Oxygen Water Corticosterone Oxygen Water 11b,21- Dihydroxy-5b- pregnane- 3,20-dione Tetrahydrocorticosterone NADP NADPH Accumulation 11- Dehydrocorticosterone 21-Hydroxy- 5b-pregnane- 3,11,20- trione NADP 3a,21- Dihydroxy-5b- pregnane- 11,20-dione NADPH NADP NADPH 11b- Hydroxyprogesterone 21- Deoxycortisol Cortisol Accumulation Deoxycorticosterone 21- Hydroxypregnenolone NAD NADH Accumulation Pregnenolone NAD NADH 17- Hydroxyprogesterone Cortexolone 17a- Hydroxypregnenolone NAD NADH NADH 17α,21- Dihydroxypregnenolone NAD 20a,22b- Dihydroxycholesterol 4- Methylpentanal 17a,20a- Dihydroxycholesterol 22b- Hydroxycholesterol 20α- Hydroxycholesterol 17a,21- Dihydroxy-5b- pregnane- 3,11,20- trione NADP Cortisone NADPH Tetrahydrocortisone NADP NADPH Dihydrocortisol NADP NADPH Tetrahydrocortisol NADP NADPH Oxygen 11b,17a,21- Trihydroxypreg- nenolone Water NADPH 5a-Pregnane- 3,20-dione NADP 3a-Hydroxy- 5b-pregnane- 20-one NADP NADPH NADP NADPH Steroid Biosynthesis
Akr1c9 Akr1d1 Cyp11b3 Cyp11b3 Akr1c9 Hsd11b1 Akr1c9 Cyp21 Cyp17a1 Cyp21 Cyp11b3 Hsd3b5 Cyp21 Hsd3b5 Cyp11b3 Cyp21 Cyp11b3 Cyp11b3 Cyp17a1 Cyp21 Hsd3b5 Hsd3b5 Cyp17a1 Cyp21 Cyp11a1 Cyp11a1 Cyp11a1 Cyp11a1 Cyp11a1 Cyp11a1 Cyp17a1 Akr1d1 Akr1c9 Akr1d1 Akr1c9 Cyp11b3 Akr1d1 Akr1c9 Hsd11b2 Hsd11b2 Hsd3b5 Lanol Accumulation Prgstrn Accumulation Prgstrn NA NADPH T20OPal NADP NADP Aldostr NADPH 18-HCC O2 H2O Cortcos O2 H2O 11B21D5 Tetrahy NADP NADPH Accumulation 11dhccn 21-Hydr NADP 321D5B NADPH NADP NADPH 11Hprgt 21HOCrt HC Accumulation Doct 21-Hpgn NAD NADH Accumulation Pregnen NAD NADH 17-OHP Cortexo 17a-HP NAD NADH NADH 17ADhp NAD OH2chol 4-MPnal 17aDhch 22b-HC 20a-HC DHPRGT NADP Corlin NADPH TetraHC NADP NADPH DHCort NADP NADPH tetHCol NADP NADPH O2 Trihpnn H2O NADPH P3D NADP 3aH5bPO NADP NADPH NADP NADPH Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme PW000050 Adrenal Gland Smooth Endoplasmic Reticulum Smooth Endoplasmic Reticulum ER Membrane ER Membrane ER Membrane Mitochondrion Mitochondrion Mitochondrion Mitochondrion Intracellular Space Extracellular Space Inner mitochondria membrane Outer mitochondria membrane
Endoplasmic Reticulum Mitochondria Endoplasmic Reticulum Akr1c9 Akr1d1 Cyp11b3 Cyp11b3 Akr1c9 Hsd11b1 Akr1c9 Cyp21 Cyp17a1 Cyp21 Cyp11b3 Hsd3b5 Cyp21 Hsd3b5 Cyp11b3 Cyp21 Cyp11b3 Cyp11b3 Cyp17a1 Cyp21 Hsd3b5 Hsd3b5 Cyp17a1 Cyp21 Cyp11a1 Cyp11a1 Cyp11a1 Cyp11a1 Cyp11a1 Cyp11a1 Cyp17a1 Akr1d1 Akr1c9 Akr1d1 Akr1c9 Cyp11b3 Akr1d1 Akr1c9 Hsd11b2 Hsd11b2 Hsd3b5 Lanol Accumulation Prgstrn Accumulation Prgstrn NA NADPH T20OPal NADP NADP Aldostr NADPH 18-HCC O2 H2O Cortcos O2 H2O 11B21D5 Tetrahy NADP NADPH Accumulation 11dhccn 21-Hydr NADP 321D5B NADPH NADP NADPH 11Hprgt 21HOCrt HC Accumulation Doct 21-Hpgn NAD NADH Accumulation Pregnen NAD NADH 17-OHP Cortexo 17a-HP NAD NADH NADH 17ADhp NAD OH2chol 4-MPnal 17aDhch 22b-HC 20a-HC DHPRGT NADP Corlin NADPH TetraHC NADP NADPH DHCort NADP NADPH tetHCol NADP NADPH O2 Trihpnn H2O NADPH P3D NADP 3aH5bPO NADP NADPH NADP NADPH PW000050