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Ptch1 SMO 5'-nucleotidase Sonic hedgehog protein Protein patched homolog 1 Smoothened homolog Glycogen synthase kinase-3 beta cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit cAMP-dependent protein kinase type II-beta regulatory subunit Zinc finger protein GLI1 Zinc finger protein GLI2 Transcriptional activator GLI3 Suppressor of fused homolog Dual specificity tyrosine- phosphorylation- regulated kinase 1A Dual specificity tyrosine- phosphorylation- regulated kinase 1B Sonic hedgehog protein Protein patched homolog 1 Smoothened homolog Glycogen synthase kinase-3 beta cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit gamma cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-beta regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit cAMP-dependent protein kinase type II-beta regulatory subunit Zinc finger protein GLI1 Zinc finger protein GLI2 Transcriptional activator GLI3 Suppressor of fused homolog Dual specificity tyrosine- phosphorylation- regulated kinase 1A Dual specificity tyrosine- phosphorylation- regulated kinase 1B ? ? cAMP ? ? cAMP Transcriptional Regulation Transcriptional Regulation Extracellular Cytoplasm Nucleus Proliferation Extracellular Cytoplasm Nucleus Proliferation
Nucleus Nucleus Ptch1 SMO NT5E SHH PTCH1 SMO GSK3B PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B GLI1 GLI2 GLI3 SUFU DYRK1A DYRK1B SHH PTCH1 SMO GSK3B PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B GLI1 GLI2 GLI3 SUFU DYRK1A DYRK1B cAMP cAMP Transcriptional Regulation Transcriptional Regulation
Ptch1 SMO NT5E SHH PTCH1 SMO GSK3B PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B GLI1 GLI2 GLI3 SUFU DYRK1A DYRK1B SHH PTCH1 SMO GSK3B PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B GLI1 GLI2 GLI3 SUFU DYRK1A DYRK1B ? ? cAMP ? ? cAMP TR TR Extracellular Cytoplasm Nucleus Proliferation Extracellular Cytoplasm Nucleus Proliferation
Nucleus Nucleus Ptch1 SMO NT5E SHH PTCH1 SMO GSK3B PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B GLI1 GLI2 GLI3 SUFU DYRK1A DYRK1B SHH PTCH1 SMO GSK3B PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B GLI1 GLI2 GLI3 SUFU DYRK1A DYRK1B cAMP cAMP TR TR