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Pathway Description
Polyketide type II Biosynthesis
Bacteria
Metabolic Pathway
Polyketides are a large family of natural products found in bacteria, fungi and plants, and include many clinically important drugs such as tetracycline, daunorubicin, erythromycin,
rapamycin and lovastatin. They are biosynthesized from acyl CoA precursors by polyketide synthases (PKSs).
References
Polyketide type II Biosynthesis References
Hertweck C, Luzhetskyy A, Rebets Y, Bechthold A: Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. Nat Prod Rep. 2007 Feb;24(1):162-90. doi: 10.1039/b507395m. Epub 2006 Nov 22.
Pubmed: 17268612
Rawlings BJ: Biosynthesis of polyketides (other than actinomycete macrolides). Nat Prod Rep. 1999 Aug;16(4):425-84.
Pubmed: 10467738
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