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Vitamin K epoxide reductase complex subunit 1 Vitamin K-dependent gamma-carboxylase Coagulation factor XIa Coagulation factor XIa Coagulation factor XIIa Coagulation factor IX Coagulation factor IXa Coagulation factor VIII Tenase complex Tenase complex Coagulation factor X Coagulation factor Xa Coagulation factor V Prothrombinase Complex Prothrombinase Complex Thrombin Thrombin Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibrin (loose) Fibrinogen beta chain Fibrinogen gamma chain Coagulation factor XIII A chain Coagulation factor XIII B chain Coagulation factor XIIIa Coagulation factor XIIIa Thrombin Vitamin K1 2,3-epoxide Reduced Vitamin K (phylloquinone) Calcium Cortexolone Calcium Calcium Calcium Calcium Calcium Calcium Calcium Warfarin Precursors of Prothrombin and coagulation factors VII, IX, ad X Prothrombin and coagulation factors VII, IX and X Inhibition of Vitamin K reductase leads to depletion of reduced Vitamin K, inhibiting coagulation factors and reducing clotting Thrombin converts fibrinogen to loose fibrin, which polymerizes to form clots Thrombin also converts coagulation factor XIII into factor XIIIa, which croisslinks fibrin, solidifying the clot Cytosol Lack of Vitamin K regeneration leads to a decrease in coagulation factors in the blood stream
VKORC1 Ggcx Unknown Unknown F12 F9 F9 F8 F8 F9 F10 F10 F5 F5 F10 Unknown Unknown Unknown Unknown FGG Unknown Unknown FGG F13A1 Unknown F13A1 Unknown Unknown Vitamin K1 2,3-epoxide Reduced Vitamin K (phylloquinone) Warfarin Precursors of Prothrombin and coagulation factors VII, IX, ad X Prothrombin and coagulation factors VII, IX and X