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5'-nucleotidase DNA topoisomerase 2-alpha DNA topoisomerase 2-beta Multidrug resistance protein 1 Canalicular multispecific organic anion transporter 2 Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 UDP- glucuronosyltransferase 1-1 Cytochrome P450 3A4 Cytochrome P450 3A5 Myeloperoxidase Etoposide Etoposide catechol Etoposide ortho-quinone Etoposide Uridine diphosphate glucuronic acid Etoposide glucuronide Uridine 5'-diphosphate O2 NADH Etoposide catechol H2O Formaldehyde NAD NAD Etoposide ortho-quinone NADH H2O ATP Pi ADP H2O ATP Pi ADP VU Magnesium Magnesium Heme Heme Heme Heme Calcium Heme tRNA(Ala) Oxidative DNA Damage (Cell Death) Lysosome Nucleus Endoplasmic Reticulum
Endoplasmic Reticulum NT5E TOP2A TOP2B ABCB1 ABCC3 PTGS1 PTGS2 UGT1A1 CYP3A4 CYP3A5 MPO Etoposide Etoposide catechol Etoposide ortho-quinone Etoposide Uridine diphosphate glucuronic acid Etoposide glucuronide Uridine 5'-diphosphate Oxygen NADH Etoposide catechol Water Formaldehyde NAD NAD Etoposide ortho-quinone NADH Water Adenosine triphosphate Phosphate Adenosine diphosphate Water Adenosine triphosphate Phosphate Adenosine diphosphate VU tRNA(Ala) Oxidative DNA Damage (Cell Death)
NT5E TOP2A TOP2B ABCB1 ABCC3 PTGS1 PTGS2 UGT1A1 CYP3A4 CYP3A5 MPO VP-16 Etopcat EtpOQn VP-16 UDPGlcA EtpGlu UDP O2 NADH Etopcat H2O Formol NAD NAD EtpOQn NADH H2O ATP Pi ADP H2O ATP Pi ADP VU Mg2+ Mg2+ Heme Heme Heme Heme Ca2+ Heme TRNAALA O D D C Lysosome Nucleus Endoplasmic Reticulum
Endoplasmic Reticulum NT5E TOP2A TOP2B ABCB1 ABCC3 PTGS1 PTGS2 UGT1A1 CYP3A4 CYP3A5 MPO VP-16 Etopcat EtpOQn VP-16 UDPGlcA EtpGlu UDP O2 NADH Etopcat H2O Formol NAD NAD EtpOQn NADH H2O ATP Pi ADP H2O ATP Pi ADP VU TRNAALA O D D C