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Sodium/glutamate
symport carrier
protein
Proton
glutamate
symport protein
Glutamyl-tRNA
synthetase
Glutamyl-tRNA
reductase
Glutamate-1-
semialdehyde
2,1-aminomutase
Delta-
aminolevulinic
acid dehydratase
Porphobilinogen
deaminase
Uroporphyrinogen-
III synthase
Uroporphyrinogen
decarboxylase
Uroporphyrinogen
decarboxylase
Coproporphyrinogen-
III oxidase,
aerobic
Oxygen-
independent
coproporphyrinogen-
III oxidase
Protoheme IX
farnesyltransferase
Catalase HPII
Siroheme synthase
Siroheme synthase
Siroheme synthase
Siroheme synthase
Protoporphyrinogen
oxidase
Siroheme synthase
Ferrochelatase
Protoporphyrinogen
oxidase
Glutamate/aspartate
transport
ATP-binding
protein gltL
Glutamate/aspartate
transport
system permease
protein gltK
Glutamate/aspartate
transport
system permease
protein gltJ
Glutamate/aspartate
periplasmic-
binding protein
L-Glutamic acid
Siroheme
Heme D
ferroheme b
Heme O
L-Glutamic acid
Na+
Na+
H+
H+
L-Glutamic acid
H+
ATP
AMP
PPi
NADPH
NADP
(S)-4-amino-5-
oxopentanoate
5-Aminolevulinic
acid
H+
H2 O
Porphobilinogen
H2 O
Ammonium
Hydroxymethylbilane
H2 O
Uroporphyrinogen
III
Uroporphyrinogen
I
H2 O
H+
CO2
Coproporphyrinogen
III
Hydrogen Ion
CO2
Coproporphyrinogen
I
H+
O2
H2 O
CO2
Protoporphyrinogen
IX
S-
Adenosylmethionine
5'-Deoxyadenosine
L-Methionine
CO2
H2 O
Farnesyl
pyrophosphate
PPi
H2 O2
S-
Adenosylmethionine
H+
S-
Adenosylhomocysteine
Precorrin-1
S-
Adenosylmethionine
Precorrin-2
S-
Adenosylhomocysteine
NAD
NADH
H+
Sirohydrochlorin
Fe2+
H+
menaquinone-8
Protoporphyrin IX
Menaquinol 6
Precorrin 2
NAD
NADH
H+
Fe2+
H+
O2
H2 O2
L-Glutamic acid
ATP
H2 O
ADP
Pi
H+
Pyridoxal
5'-phosphate
Zinc
dipyrromethane
Manganese
4Fe-4S
Magnesium
Heme D
Flavin
Mononucleotide
Flavin
Mononucleotide
Protoporphyrinogen
IX
tRNA(Glu)
L-Glutamyl-
tRNA(Glu)
tRNA(Glu)
L-Glutamate
Metabolism
Sulfur
Metabolism
Oxidative
Phosphorylation
Oxidative
Phosphorylation
Oxidative
Phosphorylation
AEROBIC
ANAEROBIC
gltS
gltP
gltX
hemA
hemL
hemB
hemC
hemD
hemE
hemE
hemF
hemN
cyoE
katE
cysG
cysG
cysG
cysG
hemG
cysG
hemH
hemG
gltL
gltK
gltJ
gltI
L-Glutamic acid
Siroheme
Heme D
ferroheme b
Heme O
L-Glutamic acid
Sodium
Sodium
Hydrogen Ion
Hydrogen Ion
L-Glutamic acid
Hydrogen Ion
Adenosine
triphosphate
Adenosine
monophosphate
Pyrophosphate
NADPH
NADP
(S)-4-amino-5-
oxopentanoate
5-Aminolevulinic
acid
Hydrogen Ion
Water
Porphobilinogen
Water
Ammonium
Hydroxymethylbilane
Water
Uroporphyrinogen
III
Uroporphyrinogen
I
Water
Hydrogen Ion
Carbon dioxide
Coproporphyrinogen
III
Hydrogen Ion
Carbon dioxide
Coproporphyrinogen
I
Hydrogen Ion
Oxygen
Water
Carbon dioxide
Protoporphyrinogen
IX
S-
Adenosylmethionine
5'-Deoxyadenosine
L-Methionine
Carbon dioxide
Water
Farnesyl
pyrophosphate
Pyrophosphate
Hydrogen peroxide
S-
Adenosylmethionine
Hydrogen Ion
S-
Adenosylhomocysteine
Precorrin-1
S-
Adenosylmethionine
Precorrin-2
S-
Adenosylhomocysteine
NAD
NADH
Hydrogen Ion
Sirohydrochlorin
Fe2+
Hydrogen Ion
menaquinone-8
Protoporphyrin IX
Menaquinol 6
Precorrin 2
NAD
NADH
Hydrogen Ion
Fe2+
Hydrogen Ion
Oxygen
Hydrogen peroxide
L-Glutamic acid
Adenosine
triphosphate
Water
Adenosine
diphosphate
Phosphate
Hydrogen Ion
Protoporphyrinogen
IX
tRNA(Glu)
L- Glutamyl-
tRNA(Glu)
tRNA(Glu)
L-Glutamate
Metabolism
Sulfur Metabolism
Oxidative
Phosphorylation
Oxidative
Phosphorylation
Oxidative
Phosphorylation
gltS
gltP
gltX
hemA
hemL
hemB
hemC
hemD
hemE
hemE
hemF
hemN
cyoE
katE
cysG
cysG
cysG
cysG
hemG
cysG
hemH
hemG
gltL
gltK
gltJ
gltI
Glu
Sheme
Heme D
FB
Heme O
Glu
Na+
Na+
H+
H+
Glu
H+
ATP
AMP
PPi
NADPH
NADP
LG1S
5-Amnva
H+
H2 O
PBG
H2 O
Ammon
HMBilan
H2 O
Urppr3
Uropg1
H2 O
H+
CO2
Coprgn3
H+
CO2
CPPgen
H+
O2
H2 O
CO2
Protop9
SAMe
CH3Ado
Met
CO2
H2 O
FarPP
PPi
H2 O2
SAMe
H+
SAH
Precor1
SAMe
P2
SAH
NAD
NADH
H+
Sirohyc
Fe2+
H+
menaqn8
PrtopIX
Menaqui
Precor2
NAD
NADH
H+
Fe2+
H+
O2
H2 O2
Glu
ATP
H2 O
ADP
Pi
H+
Pyr-5'P
Zinc
dpyram
Mn2+
4Fe-4S
Mg2+
Heme D
FlvnMnt
FlvnMnt
Protop9
TRNAGLU
LGTG
TRNAGLU
PW000789
PW000922
PW000919
PW000919
PW000919
AEROBIC
ANAEROBIC
gltS
gltP
gltX
hemA
hemL
hemB
hemC
hemD
hemE
hemE
hemF
hemN
cyoE
katE
cysG
cysG
cysG
cysG
hemG
cysG
hemH
hemG
gltL
gltK
gltJ
gltI
Glu
Sheme
Heme D
FB
Heme O
Glu
Na+
Na+
H+
H+
Glu
H+
ATP
AMP
Ppi
NADPH
NADP
LG1S
5-Amnva
H+
H2O
PBG
H2O
Ammon
HMBilan
H2O
Urppr3
Uropg1
H2O
H+
CO2
Coprgn3
H+
CO2
CPPgen
H+
O2
H2O
CO2
Protop9
SAMe
CH3Ado
Met
CO2
H2O
FarPP
Ppi
H2O2
SAMe
H+
SAH
Precor1
SAMe
P2
SAH
NAD
NADH
H+
Sirohyc
Fe2+
H+
menaqn8
PrtopIX
Menaqui
Precor2
NAD
NADH
H+
Fe2+
H+
O2
H2O2
Glu
ATP
H2O
ADP
Pi
H+
Protop9
TRNAGLU
LGTG
TRNAGLU
PW000789
PW000922
PW000919
PW000919
PW000919