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2-amino-3- carboxymuconate- 6- semialdehyde decarboxylase 2-aminomuconic semialdehyde dehydrogenase Unknown Unknown Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial Dihydrolipoyllysine- residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial Dihydrolipoyl dehydrogenase, mitochondrial 2-Amino-3- carboxymuconic acid semialdehyde Glutaryl-CoA H+ 2-Aminomuconic acid semialdehyde CO2 H2O NAD 2-Aminomuconic acid H+ NADH H2O (3E)-2- oxohex-3- enedioate Ammonium H+ NADH Oxoadipic acid NAD CoA NAD NADH CO2 Thiamine pyrophosphate Lipoamide FAD L-tryptophan degradation Glutaryl-CoA degradation Mitochondria Cytosol
Mitochondria ACMSD ALDH8A1 Unknown Unknown DHTKD1 DLST DLD 2-Amino-3- carboxymuconic acid semialdehyde Glutaryl-CoA Hydrogen Ion 2-Aminomuconic acid semialdehyde Carbon dioxide Water NAD 2-Aminomuconic acid Hydrogen Ion NADH Water (3E)-2- oxohex-3- enedioate Ammonium Hydrogen Ion NADH Oxoadipic acid NAD Coenzyme A NAD NADH Carbon dioxide L-tryptophan degradation Glutaryl-CoA degradation
ACMSD ALDH8A1 DHTKD1 DLST DLD 2Am3CSa GlutCoA H+ 2-AaSa CO2 H2O NAD 2-Ama H+ NADH H2O 3E2o3e Ammon H+ NADH Oxoadip NAD CoA NAD NADH CO2 ThiamPP Lipoamd FAD L-tr de Gl-Co d Mitochondria Cytosol
Mitochondria ACMSD ALDH8A1 DHTKD1 DLST DLD 2Am3CSa GlutCoA H+ 2-AaSa CO2 H2O NAD 2-Ama H+ NADH H2O 3E2o3e Ammon H+ NADH Oxoadip NAD CoA NAD NADH CO2 L-tr de Gl-Co d