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N-acetylglutamate
synthase
Acetylglutamate
kinase
Succinylornithine
transaminase/acetylornithine
aminotransferase
Carbamoyl-
phosphate
synthase large
chain
Carbamoyl-
phosphate
synthase small
chain
Argininosuccinate
synthase
Argininosuccinate
lyase
Arginine N-
succinyltransferase
subunit beta
N-
succinylarginine
dihydrolase
Succinylornithine
transaminase/acetylornithine
aminotransferase
N-
succinylglutamate
5-semialdehyde
dehydrogenase
Succinylglutamate
desuccinylase
Glutamine
synthetase
Gamma-
glutamylputrescine
oxidoreductase
NAD/NADP-
dependent betaine
aldehyde
dehydrogenase
Succinylornithine
transaminase/acetylornithine
aminotransferase
NAD/NADP-
dependent betaine
aldehyde
dehydrogenase
5-aminovalerate
aminotransferase
DavT
5-aminovalerate
aminotransferase
DavT
Glutarate-
semialdehyde
dehydrogenase
DavD
Acetylornithine
deacetylase
Biodegradative
arginine
decarboxylase
N-acetyl-gamma-
glutamyl-
phosphate
reductase
Ornithine
carbamoyltransferase,
catabolic
Ornithine
carbamoyltransferase,
catabolic
Guanidinobutyrase
Peptidase C26
family protein
Glutarate-
semialdehyde
dehydrogenase
DavD
Succinic acid
Succinic acid
L-Glutamic acid
Acetyl-CoA
CoA
H+
N-Acetyl-L-
glutamic acid
ATP
ADP
N-Acetyl-L-
glutamyl
5-phosphate
N-Acetyl-L-
glutamate
5-semialdehyde
L-Glutamic acid
Oxoglutaric acid
N-Acetylornithine
HCO3 -
H2 O
L-Glutamine
ATP
ADP
Pi
L-Glutamic acid
H+
Carbamoyl
phosphate
ATP
Citrulline
L-Aspartic acid
PPi
AMP
Argininosuccinic
acid
Fumaric acid
L-Arginine
Succinyl-CoA
CoA
H+
N2-succinyl-L-
arginine
H2 O
H+
CO2
Ammonium
N2-Succinyl-L-
ornithine
Oxoglutaric acid
L-Glutamic acid
N2-Succinyl-L-
glutamic acid
5-semialdehyde
H2 O
NAD
H+
NADH
N2-
succinylglutamate
H2 O
L-Glutamic acid
Putrescine
ATP
L-Glutamic acid
Pi
ADP
H+
γ-glutamyl-L-
putrescine
O2
H2 O
4-(γ-
glutamylamino)butanal
Ammonium
H2 O2
H2 O
NADP
4-(Glutamylamino)
butanoate
H+
NADPH
Oxoglutaric acid
L-Glutamic acid
4-
Aminobutyraldehyde
H2 O
NAD
H+
NADH
γ-Aminobutyric
acid
Oxoglutaric acid
Succinic acid
semialdehyde
L-Glutamic acid
NAD
H2 O
H+
NADH
H2 O
Ornithine
Acetic acid
H+
Agmatine
CO2
NADPH
H+
NADP
Pi
Pi
H+
H2 O
Urea
H2 O
L-Glutamic acid
H2 O
NADP
NADPH
H+
TCA Cycle
TCA Cycle
rmlD
argB
aruC
carB
carA
argG
argH
aruG
astB
aruC
astD
astE
glnA
puuB
betB
aruC
betB
davT
davT
davD
HV87_05345
adiA_1
argC
arcB
arcB
gbuA
CSB93_1578
davD
Succinic acid
Succinic acid
L-Glutamic acid
Acetyl-CoA
Coenzyme A
Hydrogen Ion
N-Acetyl-L-
glutamic acid
Adenosine
triphosphate
Adenosine
diphosphate
N-Acetyl-L-
glutamyl
5-phosphate
N-Acetyl-L-
glutamate
5-semialdehyde
L-Glutamic acid
Oxoglutaric acid
N-Acetylornithine
Hydrogen
carbonate
Water
L-Glutamine
Adenosine
triphosphate
Adenosine
diphosphate
Phosphate
L-Glutamic acid
Hydrogen Ion
Carbamoyl
phosphate
Adenosine
triphosphate
Citrulline
L-Aspartic acid
Pyrophosphate
Adenosine
monophosphate
Argininosuccinic
acid
Fumaric acid
L-Arginine
Succinyl-CoA
Coenzyme A
Hydrogen Ion
N2-succinyl-L-
arginine
Water
Hydrogen Ion
Carbon dioxide
Ammonium
N2-Succinyl-L-
ornithine
Oxoglutaric acid
L-Glutamic acid
N2-Succinyl-L-
glutamic acid
5-semialdehyde
Water
NAD
Hydrogen Ion
NADH
N2-
succinylglutamate
Water
L-Glutamic acid
Putrescine
Adenosine
triphosphate
L-Glutamic acid
Phosphate
Adenosine
diphosphate
Hydrogen Ion
γ-glutamyl-L-
putrescine
Oxygen
Water
4-(γ-
glutamylamino)butanal
Ammonium
Hydrogen peroxide
Water
NADP
4-(Glutamylamino)
butanoate
Hydrogen Ion
NADPH
Oxoglutaric acid
L-Glutamic acid
4-
Aminobutyraldehyde
Water
NAD
Hydrogen Ion
NADH
γ-Aminobutyric
acid
Oxoglutaric acid
Succinic acid
semialdehyde
L-Glutamic acid
NAD
Water
Hydrogen Ion
NADH
Water
Ornithine
Acetic acid
Hydrogen Ion
Agmatine
Carbon dioxide
NADPH
Hydrogen Ion
NADP
Phosphate
Phosphate
Hydrogen Ion
Water
Urea
Water
L-Glutamic acid
Water
NADP
NADPH
Hydrogen Ion
TCA Cycle
TCA Cycle
rmlD
argB
aruC
carB
carA
argG
argH
aruG
astB
aruC
astD
astE
glnA
puuB
betB
aruC
betB
davT
davT
davD
HV87_05345
adiA_1
argC
arcB
arcB
gbuA
CSB93_1578
davD
Succini
Succini
Glu
Ac-CoA
CoA
H+
NAcGlu
ATP
ADP
NALg5p
ALG5S
Glu
AKG
N-AcyOt
HCO3 -
H2 O
Gln
ATP
ADP
Pi
Glu
H+
CarbmP
ATP
Citruln
Asp
PPi
AMP
ASA
Fumarat
Arg
Suc-CoA
CoA
H+
N2sLa
H2 O
H+
CO2
Ammon
NSLO
AKG
Glu
NSLG5S
H2 O
NAD
H+
NADH
N2sg
H2 O
Glu
Putrsce
ATP
Glu
Pi
ADP
H+
γGLUPUT
O2
H2 O
4gGaBal
Ammon
H2 O2
H2 O
NADP
4GaBn
H+
NADPH
AKG
Glu
4A
H2 O
NAD
H+
NADH
GABA
AKG
SuccASA
Glu
NAD
H2 O
H+
NADH
H2 O
Ornithi
Acoh
H+
Agmatin
CO2
NADPH
H+
NADP
Pi
Pi
H+
H2 O
Urea
H2 O
Glu
H2 O
NADP
NADPH
H+
PW000779
PW000779
rmlD
argB
aruC
carB
carA
argG
argH
aruG
astB
aruC
astD
astE
glnA
puuB
betB
aruC
betB
davT
davT
davD
HV87_05345
adiA_1
argC
arcB
arcB
gbuA
CSB93_1578
davD
Succini
Succini
Glu
Ac-CoA
CoA
H+
NAcGlu
ATP
ADP
NALg5p
ALG5S
Glu
AKG
N-AcyOt
HCO3
H2O
Gln
ATP
ADP
Pi
Glu
H+
CarbmP
ATP
Citruln
Asp
Ppi
AMP
ASA
Fumarat
Arg
Suc-CoA
CoA
H+
N2sLa
H2O
H+
CO2
Ammon
NSLO
AKG
Glu
NSLG5S
H2O
NAD
H+
NADH
N2sg
H2O
Glu
Putrsce
ATP
Glu
Pi
ADP
H+
γGLUPUT
O2
H2O
4gGaBal
Ammon
H2O2
H2O
NADP
4GaBn
H+
NADPH
AKG
Glu
4A
H2O
NAD
H+
NADH
GABA
AKG
SuccASA
Glu
NAD
H2O
H+
NADH
H2O
Ornithi
Acoh
H+
Agmatin
CO2
NADPH
H+
NADP
Pi
Pi
H+
H2O
Urea
H2O
Glu
H2O
NADP
NADPH
H+
PW000779
PW000779