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Indoleamine 2,3-dioxygenase 1 Kynurenine formamidase Nitric oxide synthase, inducible Arginase-1 Argininosuccinate synthase Argininosuccinate lyase Indoleamine 2,3-dioxygenase 1 Kynurenine formamidase Nitric oxide synthase, inducible Arginase-1 Argininosuccinate synthase Argininosuccinate lyase L-Tryptophan NO Sarcosine L-Tryptophan NO Sarcosine O2 N'- Formylkynurenine H2O L-Kynurenine Formic acid H+ NADPH O2 L-Arginine Citrulline NADP H2O H2O Ornithine Urea ATP L-Aspartic acid AMP PPi Argininosuccinic acid Fumaric acid O2 N'- Formylkynurenine H2O L-Kynurenine Formic acid H+ NADPH O2 L-Arginine Citrulline NADP H2O H2O Ornithine Urea ATP L-Aspartic acid AMP PPi Argininosuccinic acid Fumaric acid 1-Methylhistidine Heme Heme FAD Flavin Mononucleotide Tetrahydrobiopterin Heme Heme FAD Flavin Mononucleotide Tetrahydrobiopterin Immune Response Tissue Repair Elimination of virus Viral antigens Excessive Inflamation Immune Response Tissue Repair Elimination of virus Viral antigens Excessive Inflamation Manganese Manganese T Cell Cytosol T Cell Cytosol
IDO1 AFMID NOS2 ARG1 ASS1 ASL IDO1 AFMID NOS2 ARG1 ASS1 ASL L-Tryptophan Nitric oxide Sarcosine L-Tryptophan Nitric oxide Sarcosine Oxygen N'- Formylkynurenine Water L-Kynurenine Formic acid Hydrogen Ion NADPH Oxygen L-Arginine Citrulline NADP Water Water Ornithine Urea Adenosine triphosphate L-Aspartic acid Adenosine monophosphate Pyrophosphate Argininosuccinic acid Fumaric acid Oxygen N'- Formylkynurenine Water L-Kynurenine Formic acid Hydrogen Ion NADPH Oxygen L-Arginine Citrulline NADP Water Water Ornithine Urea Adenosine triphosphate L-Aspartic acid Adenosine monophosphate Pyrophosphate Argininosuccinic acid Fumaric acid 1-Methylhistidine Immune Response Tissue Repair Elimination of virus Viral antigens Excessive Inflamation Immune Response Tissue Repair Elimination of virus Viral antigens Excessive Inflamation
IDO1 AFMID NOS2 ARG1 ASS1 ASL IDO1 AFMID NOS2 ARG1 ASS1 ASL Trp NO Sar Trp NO Sar O2 Formylk H2O L-Kynr Formate H+ NADPH O2 Arg Citruln NADP H2O H2O Ornithi Urea ATP Asp AMP PPi ASA Fumarat O2 Formylk H2O L-Kynr Formate H+ NADPH O2 Arg Citruln NADP H2O H2O Ornithi Urea ATP Asp AMP PPi ASA Fumarat 1-Mhis Heme Heme FAD FlvnMnt BH4 Heme Heme FAD FlvnMnt BH4 Imm Res Tis Rep El of v Vir ant Exc Inf Imm Res Tis Rep El of v Vir ant Exc Inf Mn2+ Mn2+ T Cell Cytosol T Cell Cytosol
IDO1 AFMID NOS2 ARG1 ASS1 ASL IDO1 AFMID NOS2 ARG1 ASS1 ASL Trp NO Sar Trp NO Sar O2 Formylk H2O L-Kynr Formate H+ NADPH O2 Arg Citruln NADP H2O H2O Ornithi Urea ATP Asp AMP Ppi ASA Fumarat O2 Formylk H2O L-Kynr Formate H+ NADPH O2 Arg Citruln NADP H2O H2O Ornithi Urea ATP Asp AMP Ppi ASA Fumarat 1-Mhis Imm Res Tis Rep El of v Vir ant Exc Inf Imm Res Tis Rep El of v Vir ant Exc Inf