Amiloride is a K+ (potassium-sparing diuretics) that works by directly blocking the epithelial sodium channel mainly in the distal convoluted tubule in the nephrons of the kidney in Homo Sapiens. This pathway focuses on the action of the diuretic Amiloride on the ENaC of the distal convoluted tubule which works by inhibiting sodium reabsorption. This promotes the loss of sodium in the sodium-potassium pump as well as water from the body, but without depleting potassium. Amiloride exerts its potassium-sparing effect through the inhibition of sodium reabsorption at the distal convoluted tubule, cortical collecting tubule, and collecting duct; this decreases the net negative potential of the tubular lumen and reduces both potassium and hydrogen secretion and their subsequent excretion. Amiloride is not an aldosterone antagonist and its effects are seen even in the absence of aldosterone. Usage of this drug alleviates symptoms of edema (swelling), oliguria (decreased urine output), high blood pressure, hypokalemia in patients taking diuretics.

Amiloride Action Pathway References