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Sodium channel protein type 5 subunit alpha Beta-2- syntrophin Beta-1- syntrophin Alpha-1- syntrophin Potassium voltage-gated channel subfamily E member 2 Potassium voltage-gated channel subfamily H member 2 Putative Dol-P- Glc:Glc(2)Man(9)GlcNAc(2)- PP-Dol alpha-1,2- glucosyltransferase Ionized Lidocaine Na+ Na+ Lidocaine Lidocaine K+ K+ H+ Ventricular Cardiomyocyte Extracellular Space Cytosol Quiniine, enters the muscle cell by passive diffusion A hydrogen ion attaches to the amine group, ionizing Lidocaine into its quaternary form Ionized Lidocaine binds to sodium ion channels, locking them in an open state and slowing depolarization Membrane potential (mV) Time (ms) By slowing depolarization, the cell cannot effectively propagate an action potential and electrical signals for ventricular contractions are slowed Normal action potential Quinidine action potential Lidocaine slows the rise of cardiac action potential through its sodium channel blockage, and shortens the repolarization period, reducing the overall duration of the action potential
SCN5A SNTB2 SNTB1 SNTA1 KCNE2 KCNH2 ALG10B Ionized Lidocaine Sodium Sodium Lidocaine Lidocaine Potassium Potassium Hydrogen Ion
SCN5A SNTB2 SNTB1 SNTA1 KCNE2 KCNH2 ALG10B Ion Lid Na+ Na+ L-Caine L-Caine K+ K+ H+ Ventricular Cardiomyocyte Extracellular Space Cytosol Quiniine, enters the muscle cell by passive diffusion A hydrogen ion attaches to the amine group, ionizing Lidocaine into its quaternary form Ionized Lidocaine binds to sodium ion channels, locking them in an open state and slowing depolarization Membrane potential (mV) Time (ms) By slowing depolarization, the cell cannot effectively propagate an action potential and electrical signals for ventricular contractions are slowed Normal action potential Quinidine action potential Lidocaine slows the rise of cardiac action potential through its sodium channel blockage, and shortens the repolarization period, reducing the overall duration of the action potential
SCN5A SNTB2 SNTB1 SNTA1 KCNE2 KCNH2 ALG10B Ion Lid Na+ Na+ L-Caine L-Caine K+ K+ H+