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Mitogen- activated protein kinase 1 Cannabinoid receptor 1 Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Adenylate cyclase type 4 cAMP-dependent protein kinase type II-beta regulatory subunit Focal adhesion kinase 1 Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Mitogen- activated protein kinase 3 Nitric oxide synthase, inducible Guanylate cyclase soluble subunit alpha-2 Guanylate cyclase soluble subunit beta-1 Sn1-specific diacylglycerol lipase alpha 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-2 Kv channel- interacting protein 2 (S)-3-Butyl- 1(3H)- isobenzofuranone 2-Arachidonylglycerol NO Ca+ Ca+ K+ K+ 2- Arachidonylglycerol ADP ATP H+ NADPH O2 L-Arginine Citrulline NADP H2O DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0) H2O Hydrogen Octadecanoate H2O PIP2(18:3(9Z,12Z,15Z)/18:1(9Z)) H+ Myo-inositol 1-phosphate Potassium voltage-gated channel subfamily D member 2 H+ MAPK/ERK Signaling Pathway Heme Flavin Mononucleotide Tetrahydrobiopterin FAD Calcium Calcium Presynaptic Neuron Synaptic Cleft Postsynaptic Neuron 2-AG is produced on demand through signalling that starts at PIP2. It is released from the postsynaptic neuron and acts in a retrograde fashion on CB1 receptors located on the presynaptic memrbane