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Pathway Description
beta-Alanine Metabolism
Arabidopsis thaliana
Metabolic Pathway
β-Alanine, otherwise known as 3-aminopropanoic acid, is a naturally occurring beta amino acid with its amino group located on the beta position of the carboxylate group. Beta-Alanine is a non-proteinogenic with zero stereocenter. β-Alanine can be formed naturally during plant’s protein synthesis through degradation of dihydrouracil, pantothenic acid and carnosine for varies purposes, such as antibacterial & antiherbivore responses. Beta-Alanine can also be formed from Beta-Aminopropionaldehyde catalyzed by Precursor of CEP12. Formation of Beta-Alanine can also be occurred though N-Carbamoyl Beta-Alanine catalyzed by Beta-Ureidopropionase. Beta-Alanine can also be generated from various other pathways such as Arginine, Proline Cyanoamino Acid, Alanine, Aspartate, and glutamate metabolisms. For further reactions, Beta-Alanine can be used in Pantothenate and CoA syntheses though the conversion to (R)-Pantothenate. It can also be converted to Malonate semialdehyde to participate in Propanoate metabolism.
References
beta-Alanine Metabolism References
Parthasarathy A, Savka MA, Hudson AO: The Synthesis and Role of beta-Alanine in Plants. Front Plant Sci. 2019 Jul 18;10:921. doi: 10.3389/fpls.2019.00921. eCollection 2019.
Pubmed: 31379903
Trexler ET, Smith-Ryan AE, Stout JR, Hoffman JR, Wilborn CD, Sale C, Kreider RB, Jager R, Earnest CP, Bannock L, Campbell B, Kalman D, Ziegenfuss TN, Antonio J: International society of sports nutrition position stand: Beta-Alanine. J Int Soc Sports Nutr. 2015 Jul 15;12:30. doi: 10.1186/s12970-015-0090-y. eCollection 2015.
Pubmed: 26175657
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