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Pathway Description
Biotin Metabolism
Arabidopsis thaliana
Metabolic Pathway
Biotin is an essential vitamin, which most plants such as Arabidopsis thaliana is capable of synthesizing on its own. Biotin also takes place in numerous carboxylation, decarboxylation and transcarboxylation reactions acting as a cofactor to transfer carbon dioxide to its respective place. Biotin transporters are vital to the regulation of biotin needs in plant cells as it plays a role in its continued use and synthesis within the plant. A.thaliana synthesis of biotin is required to help supplement heterotrophs (that cannot synthesize biotin on their own) such as humans, as it aids in many metabolic processes.
References
Biotin Metabolism References
Pinon V, Ravanel S, Douce R, Alban C: Biotin synthesis in plants. The first committed step of the pathway is catalyzed by a cytosolic 7-keto-8-aminopelargonic acid synthase. Plant Physiol. 2005 Dec;139(4):1666-76. doi: 10.1104/pp.105.070144. Epub 2005 Nov 18.
Pubmed: 16299174
Muralla R, Chen E, Sweeney C, Gray JA, Dickerman A, Nikolau BJ, Meinke D: A bifunctional locus (BIO3-BIO1) required for biotin biosynthesis in Arabidopsis. Plant Physiol. 2008 Jan;146(1):60-73. doi: 10.1104/pp.107.107409. Epub 2007 Nov 9.
Pubmed: 17993549
Cobessi D, Dumas R, Pautre V, Meinguet C, Ferrer JL, Alban C: Biochemical and structural characterization of the Arabidopsis bifunctional enzyme dethiobiotin synthetase-diaminopelargonic acid aminotransferase: evidence for substrate channeling in biotin synthesis. Plant Cell. 2012 Apr;24(4):1608-25. doi: 10.1105/tpc.112.097675. Epub 2012 Apr 30.
Pubmed: 22547782
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