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Pathway Description
Valproic Acid i.e. Sodium Valproate (New: Drug Action)
Homo sapiens
Drug Action Pathway
Sodium valproate, also known as valproic acid, is a fatty acid derivative and anticonvulsant first synthesized in 1881-1882 from an analogue derived from the Valerian herb; however, its mechanism of action is not fully elucidated (yet). Traditionally, researchers and clinicians consider it to be an anticonvulsant due to its effects in the brain: it blocks voltage-gated sodium channels and potentiates gamma-aminobutyric acid (GABA) activity. Over the past centuries, investigations show valproate may also have neuroprotective, anti-manic, and anti-migraine effects. It is a compound of interest in the field of oncology for its anti-proliferative effects and has undergone some clinical trials. Currently, valproate is indicated for use as a monotherapy or adjunct medication in seizure management, for migraine prophylaxis, and for mitigation of acute mania associated with bipolar disorder. Off-label, clinicians may use valproate to manage bipolar disorder or for emergency treatment of status epilepticus. Valproate can be administered orally, in which case it undergoes hepatic first-pass metabolism to enter the bloodstream ___________________ https://go.drugbank.com/drugs/DB00313
References
Valproic Acid i.e. Sodium Valproate (New: Drug Action) References
Muzina DJ, Gao K, Kemp DE, Khalife S, Ganocy SJ, Chan PK, Serrano MB, Conroy CM, Calabrese JR: Acute efficacy of divalproex sodium versus placebo in mood stabilizer-naive bipolar I or II depression: a double-blind, randomized, placebo-controlled trial. J Clin Psychiatry. 2011 Jun;72(6):813-9. doi: 10.4088/JCP.09m05570gre. Epub 2010 Aug 24.
Pubmed: 20816041
Schwartz TL, Massa JL, Gupta S, Al-Samarrai S, Devitt P, Masand PS: Divalproex Sodium Versus Valproic Acid in Hospital Treatment of Psychotic Disorders. Prim Care Companion J Clin Psychiatry. 2000 Apr;2(2):45-48. doi: 10.4088/pcc.v02n0203.
Pubmed: 15014582
Prasad M, Krishnan PR, Sequeira R, Al-Roomi K: Anticonvulsant therapy for status epilepticus. Cochrane Database Syst Rev. 2014 Sep 10;(9):CD003723. doi: 10.1002/14651858.CD003723.pub3.
Pubmed: 25207925
Kostrouchova M, Kostrouch Z, Kostrouchova M: Valproic acid, a molecular lead to multiple regulatory pathways. Folia Biol (Praha). 2007;53(2):37-49.
Pubmed: 17448293
Kay HY, Greene DL, Kang S, Kosenko A, Hoshi N: M-current preservation contributes to anticonvulsant effects of valproic acid. J Clin Invest. 2015 Oct 1;125(10):3904-14. doi: 10.1172/JCI79727. Epub 2015 Sep 8.
Pubmed: 26348896
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