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Pathway Description
Benazepril metabolic pathway
Homo sapiens
Metabolic Pathway
Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Cleavage of the ester group (primarily in the liver) converts benazepril to its active metabolite, benazeprilat by Cytochrome P450 3A4 in the liver. Benazepril and benazeprilat are conjugated to glucuronic acid prior to urinary excretion. Benazepril is excreted by Organic anion transporter 1.
References
Benazepril metabolic pathway References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
DeGorter MK, Xia CQ, Yang JJ, Kim RB: Drug transporters in drug efficacy and toxicity. Annu Rev Pharmacol Toxicol. 2012;52:249-73. doi: 10.1146/annurev-pharmtox-010611-134529. Epub 2011 Sep 19.
Pubmed: 21942630
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