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Pathway Description
Captopril metabolic pathway
Homo sapiens
Metabolic Pathway
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension. (DrugBank)
Major metabolites are captopril-cysteine disulfide and the disulfide dimer of captopril. Metabolites are produced by Cytochrome P450 3A4 in the liver and may undergo reversible interconversion. These metabolites are excreted via the Organic anion transporter 1 (OAT1).
References
Captopril metabolic pathway References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
DeGorter MK, Xia CQ, Yang JJ, Kim RB: Drug transporters in drug efficacy and toxicity. Annu Rev Pharmacol Toxicol. 2012;52:249-73. doi: 10.1146/annurev-pharmtox-010611-134529. Epub 2011 Sep 19.
Pubmed: 21942630
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