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Pathway Description
Minocycline
Homo sapiens
Drug Action Pathway
Minocycline is a tetracycline antibiotic drug that is used topically to treat inflammatory lesions caused by the bacteria acne vulgaris. Similarly to other tetracyclines this drug acts by suppressing the growth of the bacteria it is acting on by inhibiting protein synthesis. Minocycline binds to the 30s subunit of the bacterial ribosome which prevents aminoacyl-tRNA from binding to the A site of the mRNA ribosome complex. This prevents the protein translation process in the bacteria and therefore the protein synthesis.
References
Minocycline References
Zhanel GG, Homenuik K, Nichol K, Noreddin A, Vercaigne L, Embil J, Gin A, Karlowsky JA, Hoban DJ: The glycylcyclines: a comparative review with the tetracyclines. Drugs. 2004;64(1):63-88. doi: 10.2165/00003495-200464010-00005.
Pubmed: 14723559
Chukwudi, C. U. (2016). rRNA binding sites and the molecular mechanism of action of the tetracyclines. Antimicrobial agents and chemotherapy, 60(8), 4433-4441.
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