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Pathway Description
Doxycycline
Homo sapiens
Drug Action Pathway
Doxycycline is a tetracycline antibiotic drug that is used to treat bacterial infections. Some of these infections include typhus fever, respiratory tract fevers, and tick fevers caused by different gram-positive and gram-negative bacteria. This drug acts by suppressing the growth of the bacteria it is acting on by inhibiting protein synthesis. Doxycycline binds to the 30s subunit of the bacterial ribosome which prevents aminoacyl-tRNA from binding to the A site of the mRNA ribosome complex. This prevents the protein translation process in the bacteria and therefore the protein synthesis.
References
Doxycycline References
Pringle M, Fellstrom C, Johansson KE: Decreased susceptibility to doxycycline associated with a 16S rRNA gene mutation in Brachyspira hyodysenteriae. Vet Microbiol. 2007 Jul 20;123(1-3):245-8. doi: 10.1016/j.vetmic.2007.02.019. Epub 2007 Feb 25.
Pubmed: 17428623
Kumar S, Kutlin A, Roblin P, Kohlhoff S, Bodetti T, Timms P, Hammerschlag MR: Isolation and antimicrobial susceptibilities of Chlamydial isolates from Western barred bandicoots. J Clin Microbiol. 2007 Feb;45(2):392-4. doi: 10.1128/JCM.01726-06. Epub 2006 Nov 22.
Pubmed: 17122017
Ross JI, Eady EA, Cove JH, Cunliffe WJ: 16S rRNA mutation associated with tetracycline resistance in a gram-positive bacterium. Antimicrob Agents Chemother. 1998 Jul;42(7):1702-5. doi: 10.1128/AAC.42.7.1702.
Pubmed: 9661007
Chukwudi CU: rRNA Binding Sites and the Molecular Mechanism of Action of the Tetracyclines. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4433-41. doi: 10.1128/AAC.00594-16. Print 2016 Aug.
Pubmed: 27246781
Valentin S, Morales A, Sanchez JL, Rivera A: Safety and efficacy of doxycycline in the treatment of rosacea. Clin Cosmet Investig Dermatol. 2009 Aug 12;2:129-40. doi: 10.2147/ccid.s4296.
Pubmed: 21436975
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