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Insulin
Insulin
receptor
Pyruvate
dehydrogenase
complex
Sodium/potassium
ATPase
Sarcoplasmic/endoplasmic
reticulum
calcium ATPase
2
Sodium/potassium
ATPase
ATP synthase
subunit beta,
mitochondrial
3-
phosphoinositide-
dependent
protein kinase
1
RAC-alpha
serine/threonine-
protein kinase
Long-chain
fatty acid
transport
protein 1
Mitochondrial
carnitine/acylcarnitine
carrier protein
Solute carrier
family 2,
facilitated
glucose
transporter
member 4
Mitochondrial
pyruvate
carrier 1
Solute carrier
family 22
member 5
Long-chain-
fatty-acid--
CoA ligase 1
Carnitine O-
palmitoyltransferase
1, liver
isoform
Carnitine O-
palmitoyltransferase
2,
mitochondrial
ATP synthase
lipid-binding
protein,
mitochondrial
ATP synthase
subunit a
ATP synthase
subunit alpha,
mitochondrial
ATP synthase
subunit b,
mitochondrial
ATP synthase
subunit delta,
mitochondrial
ATP synthase
subunit
epsilon,
mitochondrial
ATP synthase
subunit gamma,
mitochondrial
RAC-alpha
serine/threonine-
protein kinase
Serine/threonine-
protein
phosphatase 2A
catalytic
subunit alpha
isoform
Carnitine O-
acetyltransferase
L-
Palmitoylcarnitine
L-
Palmitoylcarnitine
PIP3(16:0/16:0)
Palmitoyl-CoA
Acetyl-CoA
Palmitoyl-CoA
Palmitic acid
D-Glucose
Pyruvic acid
NADH
Superoxide
Palmitic acid
L-
Palmitoylcarnitine
D-Glucose
Pyruvic acid
Ca+
Ca+
Na+
Na+
K+
K+
L-Carnitine
L-Carnitine
ATP
CoA
AMP
PPi
CoA
L-Carnitine
CoA
CoA
NAD
CO2
NADH
ADP
H+
ATP
H+
L-Carnitine
L-
Acetylcarnitine
CoA
Na+
ATP
K+
H2 O
Na+
ADP
Pi
K+
Pi
Thiamine
pyrophosphate
Lipoamide
FAD
Mitochondrial
Beta-Oxidation
of Long Chain
Saturated Fatty
Acids
Activation of
peroxisomal FA
Ooxidation
Glycolysis
TCA Cycle
Mitochondrial
Electron
Transport Chain
Insulin
Signalling
AKT signaling
pathway
Pi
Pi
Magnesium
Cytosol
Mitochondrial Outer Membrane
Mitochondrial Inter-membrane
Space
Mitochondrial Inner Membrane
Mitochondrial Matrix
Extracellular Space
Mitochondria
Unknown
INSR
PDHA1
FXYD2
ATP2A2
FXYD2
ATP5B
PDPK1
AKT1
SLC27A1
SLC25A20
SLC2A4
MPC1
SLC22A5
ACSL1
CPT1A
CPT2
ATP5G2
MT-ATP6
ATP5A1
ATP5F1
ATP5D
ATP5E
ATP5C1
AKT1
PPP2CA
CRAT
L-
Palmitoylcarnitine
L-
Palmitoylcarnitine
PIP3(16:0/16:0)
Palmitoyl-CoA
Acetyl-CoA
Palmitoyl-CoA
Palmitic acid
D-Glucose
Pyruvic acid
NADH
Superoxide
Palmitic acid
L-
Palmitoylcarnitine
D-Glucose
Pyruvic acid
Calcium
Calcium
Sodium
Sodium
Potassium
Potassium
L-Carnitine
L-Carnitine
Adenosine
triphosphate
Coenzyme A
Adenosine
monophosphate
Pyrophosphate
Coenzyme A
L-Carnitine
Coenzyme A
Coenzyme A
NAD
Carbon dioxide
NADH
Adenosine
diphosphate
Hydrogen
Adenosine
triphosphate
Hydrogen
L-Carnitine
L-
Acetylcarnitine
Coenzyme A
Sodium
Adenosine
triphosphate
Potassium
Water
Sodium
Adenosine
diphosphate
Phosphate
Potassium
Phosphate
Mitochondrial
Beta-Oxidation
of Long Chain
Saturated Fatty
Acids
Activation of
peroxisomal FA
Ooxidation
Glycolysis
TCA Cycle
Mitochondrial
Electron
Transport Chain
Insulin
Signalling
AKT signaling
pathway
Phosphate
Phosphate
INSR
PDHA1
FXYD2
ATP2A2
FXYD2
ATP5B
PDPK1
AKT1
SLC27A1
SLC25A20
SLC2A4
MPC1
SLC22A5
ACSL1
CPT1A
CPT2
ATP5G2
MT-ATP6
ATP5A1
ATP5F1
ATP5D
ATP5E
ATP5C1
AKT1
PPP2CA
CRAT
L-Plmtc
L-Plmtc
PIP316
COA16:0
Ac-CoA
COA16:0
16:0
D-Glc
Pyr
NADH
O2(-)
16:0
L-Plmtc
D-Glc
Pyr
Ca+
Ca+
Na+
Na+
K+
K+
L-Carnt
L-Carnt
ATP
CoA
AMP
PPi
CoA
L-Carnt
CoA
CoA
NAD
CO2
NADH
ADP
H+
ATP
H+
L-Carnt
L-Alcar
CoA
Na+
ATP
K+
H2 O
Na+
ADP
Pi
K+
Pi
ThiamPP
Lipoamd
FAD
PW000173
A o p F
PW000146
PW002364
PW000165
PW000454
PW109148
Pi
Pi
Mg2+
Cytosol
Mitochondrial Outer Membrane
Mitochondrial Inter-membrane
Space
Mitochondrial Inner Membrane
Mitochondrial Matrix
Extracellular Space
Mitochondria
INSR
PDHA1
FXYD2
ATP2A2
FXYD2
ATP5B
PDPK1
AKT1
SLC27A1
SLC25A20
SLC2A4
MPC1
SLC22A5
ACSL1
CPT1A
CPT2
ATP5G2
MT-ATP6
ATP5A1
ATP5F1
ATP5D
ATP5E
ATP5C1
AKT1
PPP2CA
CRAT
L-Plmtc
L-Plmtc
PIP316
COA16:0
Ac-CoA
COA16:0
16:0
D-Glc
Pyr
NADH
O2(-)
16:0
L-Plmtc
D-Glc
Pyr
Ca2+
Ca2+
Na+
Na+
K+
K+
L-Carnt
L-Carnt
ATP
CoA
AMP
Ppi
CoA
L-Carnt
CoA
CoA
NAD
CO2
NADH
ADP
H2
ATP
H2
L-Carnt
L-Alcar
CoA
Na+
ATP
K+
H2O
Na+
ADP
Pi
K+
Pi
PW000173
A o p F
PW000146
PW002364
PW000165
PW000454
PW109148
Pi
Pi